Fibroblast growth factor expression during skeletal fracture healing in mice

Gregory J. Schmid, Chikashi Kobayashi, Linda J. Sandell, David M. Ornitz

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Fibroblast growth factors (FGFs) are important signaling molecules that regulate many stages of endochondral bone development. During the healing of a skeletal fracture, several features of endochondral bone development are reactivated. To better understand the role of FGFs in skeletal fracture healing, we quantitatively evaluated the temporal expression patterns of Fgfs, Fgf receptors (Fgfrs), and molecular markers of bone development over a 14-day period following long bone fracture in a mouse model. These studies identify distinct groups of FGFs that are differentially expressed and suggest active stage-specific roles for FGF signaling during the fracture repair process.

Original languageEnglish
Pages (from-to)766-774
Number of pages9
JournalDevelopmental Dynamics
Volume238
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • Endochondral ossification
  • FGF
  • Fibroblast growth factor
  • Fracture healing
  • Fracture repair

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