TY - JOUR
T1 - Fibroblast chemotaxis after tendon repair
AU - Gelberman, Richard H.
AU - Steinberg, David
AU - Amiel, David
AU - Akeson, Wayne
N1 - Funding Information:
paedic Surgery, Boston, Mass.; and the University of California, San Diego School of Medicine, La Jolla, Calif. Supported by NIH Grant AR33097. Received for publication April 25, 1990; accepted in revised form Oct. 24, 1990. No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. Reprint requests: Richard H. Gelberman, MD, Massachusetts General Hospital, Department of Orthopaedic Surgery, WACC - 527, Bos-ton, MA 02114. 3/I/26989
PY - 1991/7
Y1 - 1991/7
N2 - Healing canine flexor tendons were treated with early controlled passive mobilization. The repair site and proximal and distal tendon stumps were stained for fibronectin and examined by light microscopy at three, seven, eleven, and seventeen days. Fibronectin increased dramatically in the epitenon adjacent to the repair site seven days after repair, a time when epitenon cellular activity was at its peak. By seventeen days, fibronectin staining had decreased substantially, both at the repair site and in the tendon stumps. A delayed increase in fibronectin activity was noted in the endotenon adjacent to the repair site. Fibronectin production appears to be an important component of the early tendon repair process. Fibroblast chemotaxis and adherence to the substratum in the days after injury and repair appears to be related directly to fibronectin secretion. This study is the first to provide documentation of fibronectin localization in a clinically relevant tendon repair model.
AB - Healing canine flexor tendons were treated with early controlled passive mobilization. The repair site and proximal and distal tendon stumps were stained for fibronectin and examined by light microscopy at three, seven, eleven, and seventeen days. Fibronectin increased dramatically in the epitenon adjacent to the repair site seven days after repair, a time when epitenon cellular activity was at its peak. By seventeen days, fibronectin staining had decreased substantially, both at the repair site and in the tendon stumps. A delayed increase in fibronectin activity was noted in the endotenon adjacent to the repair site. Fibronectin production appears to be an important component of the early tendon repair process. Fibroblast chemotaxis and adherence to the substratum in the days after injury and repair appears to be related directly to fibronectin secretion. This study is the first to provide documentation of fibronectin localization in a clinically relevant tendon repair model.
UR - http://www.scopus.com/inward/record.url?scp=0025916382&partnerID=8YFLogxK
U2 - 10.1016/0363-5023(91)90195-H
DO - 10.1016/0363-5023(91)90195-H
M3 - Article
C2 - 1880367
AN - SCOPUS:0025916382
SN - 0363-5023
VL - 16
SP - 686
EP - 693
JO - Journal of Hand Surgery
JF - Journal of Hand Surgery
IS - 4
ER -