Fibrinogen uptake by thrombi: effect of thrombus age

R. E. Coleman, S. S.L. Harwig, J. F. Harwig, B. A. Siegel, M. J. Welch

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The uptake of radiolabeled fibrinogen in canine thrombi was determined at varying times after thrombus induction by electric current. The greatest thrombus/blood ratio was achieved when fibrinogen was administered 4 hr after thrombus induction, but definite thrombus fibrinogen uptake was still observed when the tracer was administered up to 72 hr after thrombus induction. There was continued fibrinogen accumulation despite a decrease in weight of older thrombi suggesting that net thrombus propagation is not necessary for labeled fibrinogen uptake. The findings suggest that the fibrinogen uptake test may be useful for the diagnosis of deep vein thrombosis for several days after the onset of thrombosis.

Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalJournal of Nuclear Medicine
Issue number5
StatePublished - Dec 1 1975


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