Fgfr3 regulates development of the caudal telencephalon

Randal X. Moldrich, Cecilia Mezzera, William M. Holmes, Sailaja Goda, Sam J. Brookfield, Alastair J. Rankin, Emily Barr, Nyoman Kurniawan, Deborah Dewar, Linda J. Richards, Guillermina López-Bendito, Tomoko Iwata

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostrallow to caudalhigh gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex. Overall, the forebrain structures appeared normal in Fgfr3-/- mice. However, cortical and hippocampal volumes were reduced by 26.7% and 16.3%, respectively. Hypoplasia was particularly evident in the caudo-ventral region of the telencephalon where proliferation was mildly decreased at embryonic day 18.5. Dysplasia of GABAergic neurons in the amygdala and piriform cortex was seen following GAD67 immunohistochemistry. Dye-tracing studies and diffusion magnetic resonance imaging and tractography detected a subtle thalamocortical tract deficit, and significant decreases in the stria terminalis and lateral arms of the anterior commissure. These results indicate the subtle role of Fgfr3 in formation of caudal regions of the telencephalon affecting some brain projections.

Original languageEnglish
Pages (from-to)1586-1599
Number of pages14
JournalDevelopmental Dynamics
Volume240
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Commissures
  • Cortical volume
  • Fgf
  • Mouse
  • Neurogenesis

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