Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination

Jennifer Schmahl, Yuna Kim, Jennifer S. Colvin, David M. Ornitz, Blanche Capel

Research output: Contribution to journalArticlepeer-review

209 Scopus citations

Abstract

Recently, we demonstrated that loss of Fgf9 results in a block of testis development and a male to female sex-reversed phenotype; however, the function of Fgf9 in sex determination was unknown. We now show that Fgf9 is necessary for two steps of testis development just downstream of the male sex-determining gene, Sry: (1) for the proliferation of a population of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors. The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.

Original languageEnglish
Pages (from-to)3627-3636
Number of pages10
JournalDevelopment
Volume131
Issue number15
DOIs
StatePublished - Aug 2004

Keywords

  • FGF
  • Gonad
  • Sertoli cell
  • Sex determination
  • Sry
  • Testes

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