FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium

Mónica Vega-Hernández, Attila Kovacs, Stijn de Langhe, David M. Ornitz

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

The epicardium serves as a source of growth factors that regulate myocardial proliferation and as a source of epicardial-derived cells (EPDC), which give rise to interstitial cardiac fibroblasts and perivascular cells. These progenitors populate the compact myocardium to become part of the mature coronary vasculature and fibrous skeleton of the heart. Little is known about the mechanisms that regulate EPDC migration into the myocardium or the functions carried out by these cells once they enter the myocardium. However, it has been proposed that cardiac fibroblasts are important for growth of the heart during late gestation and are a source of homeostatic factors in the adult. Here, we identify a myocardial to epicardial fibroblast growth factor (FGF) signal, mediated by FGF10 and FGFR2b, that is essential for movement of cardiac fibroblasts into the compact myocardium. Inactivation of this signaling pathway results in fewer epicardial derived cells within the compact myocardium, decreased myocardial proliferation and a resulting smaller thin-walled heart.

Original languageEnglish
Pages (from-to)3331-3340
Number of pages10
JournalDevelopment
Volume138
Issue number15
DOIs
StatePublished - Aug 1 2011

Keywords

  • Cardiac fibroblast
  • Cardiomyocyte
  • EPDCs
  • Epicardium
  • FGF10
  • FGFR2b

Fingerprint

Dive into the research topics of 'FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium'. Together they form a unique fingerprint.

Cite this