FGF signaling in the developing endochondral skeleton

Research output: Contribution to journalShort surveypeer-review

277 Scopus citations

Abstract

Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume16
Issue number2 SPEC. ISS.
DOIs
StatePublished - Apr 2005

Keywords

  • Achondroplasia
  • Craniosynostosis
  • FGF
  • Receptor tyrosine kinase
  • Skeletal development

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