FGF signaling in the developing endochondral skeleton

David M. Ornitz

doi:10.1016/j.cytogfr.2005.02.003

FGF signaling in the developing endochondral skeleton

David M. Ornitz

Research output: Contribution to journal › Short survey › peer-review

316 Scopus citations

Abstract

Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

Original language	English
Pages (from-to)	205-213
Number of pages	9
Journal	Cytokine and Growth Factor Reviews
Volume	16
Issue number	2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.cytogfr.2005.02.003
State	Published - Apr 2005

Keywords

Achondroplasia
Craniosynostosis
FGF
Receptor tyrosine kinase
Skeletal development

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10.1016/j.cytogfr.2005.02.003

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title = "FGF signaling in the developing endochondral skeleton",

abstract = "Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.",

keywords = "Achondroplasia, Craniosynostosis, FGF, Receptor tyrosine kinase, Skeletal development",

author = "Ornitz, {David M.}",

note = "Funding Information: This work was supported by NIH grant HD39952 and a gift from the Virginia Friedhofer Charitable Trust.",

year = "2005",

month = apr,

doi = "10.1016/j.cytogfr.2005.02.003",

language = "English",

volume = "16",

pages = "205--213",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

number = "2 SPEC. ISS.",

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TY - JOUR

T1 - FGF signaling in the developing endochondral skeleton

AU - Ornitz, David M.

N1 - Funding Information: This work was supported by NIH grant HD39952 and a gift from the Virginia Friedhofer Charitable Trust.

PY - 2005/4

Y1 - 2005/4

N2 - Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

AB - Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

KW - Achondroplasia

KW - Craniosynostosis

KW - FGF

KW - Receptor tyrosine kinase

KW - Skeletal development

UR - http://www.scopus.com/inward/record.url?scp=18144391965&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2005.02.003

DO - 10.1016/j.cytogfr.2005.02.003

M3 - Short survey

C2 - 15863035

AN - SCOPUS:18144391965

SN - 1359-6101

VL - 16

SP - 205

EP - 213

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 2 SPEC. ISS.

ER -

FGF signaling in the developing endochondral skeleton

Abstract

Keywords

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