FGF signaling in skeletal development

Michael C. Naski, David M. Ornitz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The fibroblast growth factor receptor family consists of four receptor tyrosine kinases which bind with varying affinity and specificity to a family of at least fifteen polypeptide ligands. The receptors and ligands perform many essential functions during growth, development and repair. Recent discoveries show that a growing number of skeletal abnormalities result from mutations in the fibroblast growth factor receptors. These findings have led to a greater understanding of the role of fibroblast growth factor signaling during skeletogenesis and have focused research interests on the effects of fibroblast growth factors on endochondral and intramembranous bone development.

Original languageEnglish
Pages (from-to)355-379
Number of pages25
JournalFetal and Pediatric Pathology
Volume18
Issue number4-5
DOIs
StatePublished - Dec 1 1998

Keywords

  • FGF signaling
  • endochondral ossijcation
  • intramembranous ossijcation
  • limb development
  • receptor tyrosine kinase
  • skeletal dysplasia

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