Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21

George A. Macones; Anthony Johnson; Denise Tilley; Ronald Wade; Ronald Wapner

doi:10.1159/000264219

Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21

George A. Macones, Anthony Johnson, Denise Tilley, Ronald Wade, Ronald Wapner

Division of Clinical Research

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The in utero diagnosis of fetal myeloproliferative disease was made by cordocentesis following the ultrasound appearance of fetal hepatosplenomegaly and mild hydrops. The 2 fetuses reported both had leukocyte counts greater than 75, 000/mm3 with a predominance of blast forms. In both cases the karyotype revealed trisomy 21.

Original language	English
Pages (from-to)	131-133
Number of pages	3
Journal	Fetal Diagnosis and Therapy
Volume	10
Issue number	2
DOIs	https://doi.org/10.1159/000264219
State	Published - 1995

Keywords

Down syndrome
Hepatosplenomegaly

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10.1159/000264219

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title = "Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21",

abstract = "The in utero diagnosis of fetal myeloproliferative disease was made by cordocentesis following the ultrasound appearance of fetal hepatosplenomegaly and mild hydrops. The 2 fetuses reported both had leukocyte counts greater than 75, 000/mm3 with a predominance of blast forms. In both cases the karyotype revealed trisomy 21.",

keywords = "Down syndrome, Hepatosplenomegaly",

author = "Macones, {George A.} and Anthony Johnson and Denise Tilley and Ronald Wade and Ronald Wapner",

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doi = "10.1159/000264219",

language = "English",

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pages = "131--133",

journal = "Fetal Diagnosis and Therapy",

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T1 - Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21

AU - Macones, George A.

AU - Johnson, Anthony

AU - Tilley, Denise

AU - Wade, Ronald

AU - Wapner, Ronald

PY - 1995

Y1 - 1995

N2 - The in utero diagnosis of fetal myeloproliferative disease was made by cordocentesis following the ultrasound appearance of fetal hepatosplenomegaly and mild hydrops. The 2 fetuses reported both had leukocyte counts greater than 75, 000/mm3 with a predominance of blast forms. In both cases the karyotype revealed trisomy 21.

AB - The in utero diagnosis of fetal myeloproliferative disease was made by cordocentesis following the ultrasound appearance of fetal hepatosplenomegaly and mild hydrops. The 2 fetuses reported both had leukocyte counts greater than 75, 000/mm3 with a predominance of blast forms. In both cases the karyotype revealed trisomy 21.

KW - Down syndrome

KW - Hepatosplenomegaly

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U2 - 10.1159/000264219

DO - 10.1159/000264219

M3 - Article

C2 - 7794514

AN - SCOPUS:0028901035

SN - 1015-3837

VL - 10

SP - 131

EP - 133

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

IS - 2

ER -

Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21

Abstract

Keywords

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