Fetal fibronectin

David G. Grenache, Ann M. Gronowski

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The fibronectin family of proteins is found in the extracellular matrix and plasma. Fibronectins interact with specific adhesion molecules on cell surfaces and have been implicated in the regulation of cell differentiation, proliferation, migration, and apoptosis (1). Fetal fibronectin (fFN) is an immunologically unique fibronectin that contains an epitope referred to as the oncofetal domain that is recognized by the monoclonal antibody FDC-6 (2). During gestation, fFN’s location at the choriodecidual interface suggests a role for this protein in anchoring the fetal trophoblast to the maternal decidua (3). Fetal fibronectin is released into cervicovaginal secretions before the onset of labor, and although the mechanism of this release is not clear, it has been suspected to occur by either mechanical or inflammatory mechanisms (4).

Original languageEnglish
Title of host publicationPoint-of-Care Testing
Subtitle of host publicationPerformance Improvement and Evidence-Based Outcomes
PublisherCRC Press
Pages477-489
Number of pages13
ISBN (Electronic)9781420028898
ISBN (Print)0824708687, 9780824708689
StatePublished - Jan 1 2002

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    Grenache, D. G., & Gronowski, A. M. (2002). Fetal fibronectin. In Point-of-Care Testing: Performance Improvement and Evidence-Based Outcomes (pp. 477-489). CRC Press.