Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Kristina M. Adams Waldorf; Jennifer E. Stencel-Baerenwald; Raj P. Kapur; Colin Studholme; Erica Boldenow; Jay Vornhagen; Audrey Baldessari; Manjiri K. Dighe; Jeff Thiel; Sean Merillat; Blair Armistead; Jennifer Tisoncik-Go; Richard R. Green; Michael A. Davis; Elyse C. Dewey; Marian R. Fairgrieve; J. Christopher Gatenby; Todd Richards; Gwenn A. Garden; Michael S. Diamond; Sandra E. Juul; Richard F. Grant; Larene Kuller; Dennis W.W. Shaw; Jason Ogle; G. Michael Gough; Wonsok Lee; Chris English; Robert F. Hevner; William B. Dobyns; Michael Gale; Lakshmi Rajagopal

doi:10.1038/nm.4193

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Kristina M. Adams Waldorf
, Jennifer E. Stencel-Baerenwald
, Raj P. Kapur
, Colin Studholme
, Erica Boldenow
, Jay Vornhagen
, Audrey Baldessari
, Manjiri K. Dighe
, Jeff Thiel
, Sean Merillat
, Blair Armistead
, Jennifer Tisoncik-Go
, Richard R. Green
, Michael A. Davis
, Elyse C. Dewey
, Marian R. Fairgrieve
, J. Christopher Gatenby
, Todd Richards
, Gwenn A. Garden
, Michael S. Diamond

Sandra E. Juul, Richard F. Grant, Larene Kuller, Dennis W.W. Shaw, Jason Ogle, G. Michael Gough, Wonsok Lee, Chris English, Robert F. Hevner, William B. Dobyns, Michael Gale, Lakshmi Rajagopal

Research output: Contribution to journal › Article › peer-review

231 Scopus citations

Abstract

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

Original language	English
Pages (from-to)	1256-1259
Number of pages	4
Journal	Nature medicine
Volume	22
Issue number	11
DOIs	https://doi.org/10.1038/nm.4193
State	Published - Nov 1 2016

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Adams Waldorf, K. M., Stencel-Baerenwald, J. E., Kapur, R. P., Studholme, C., Boldenow, E., Vornhagen, J., Baldessari, A., Dighe, M. K., Thiel, J., Merillat, S., Armistead, B., Tisoncik-Go, J., Green, R. R., Davis, M. A., Dewey, E. C., Fairgrieve, M. R., Gatenby, J. C., Richards, T., Garden, G. A., ... Rajagopal, L. (2016). Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nature medicine, 22(11), 1256-1259. https://doi.org/10.1038/nm.4193

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title = "Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate",

abstract = "We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.",

author = "\{Adams Waldorf\}, \{Kristina M.\} and Stencel-Baerenwald, \{Jennifer E.\} and Kapur, \{Raj P.\} and Colin Studholme and Erica Boldenow and Jay Vornhagen and Audrey Baldessari and Dighe, \{Manjiri K.\} and Jeff Thiel and Sean Merillat and Blair Armistead and Jennifer Tisoncik-Go and Green, \{Richard R.\} and Davis, \{Michael A.\} and Dewey, \{Elyse C.\} and Fairgrieve, \{Marian R.\} and Gatenby, \{J. Christopher\} and Todd Richards and Garden, \{Gwenn A.\} and Diamond, \{Michael S.\} and Juul, \{Sandra E.\} and Grant, \{Richard F.\} and Larene Kuller and Shaw, \{Dennis W.W.\} and Jason Ogle and Gough, \{G. Michael\} and Wonsok Lee and Chris English and Hevner, \{Robert F.\} and Dobyns, \{William B.\} and Michael Gale and Lakshmi Rajagopal",

year = "2016",

month = nov,

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doi = "10.1038/nm.4193",

language = "English",

volume = "22",

pages = "1256--1259",

journal = "Nature medicine",

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Adams Waldorf, KM, Stencel-Baerenwald, JE, Kapur, RP, Studholme, C, Boldenow, E, Vornhagen, J, Baldessari, A, Dighe, MK, Thiel, J, Merillat, S, Armistead, B, Tisoncik-Go, J, Green, RR, Davis, MA, Dewey, EC, Fairgrieve, MR, Gatenby, JC, Richards, T, Garden, GA, Diamond, MS, Juul, SE, Grant, RF, Kuller, L, Shaw, DWW, Ogle, J, Gough, GM, Lee, W, English, C, Hevner, RF, Dobyns, WB, Gale, M & Rajagopal, L 2016, 'Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate', Nature medicine, vol. 22, no. 11, pp. 1256-1259. https://doi.org/10.1038/nm.4193

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T1 - Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

AU - Adams Waldorf, Kristina M.

AU - Stencel-Baerenwald, Jennifer E.

AU - Kapur, Raj P.

AU - Studholme, Colin

AU - Boldenow, Erica

AU - Vornhagen, Jay

AU - Baldessari, Audrey

AU - Dighe, Manjiri K.

AU - Thiel, Jeff

AU - Merillat, Sean

AU - Armistead, Blair

AU - Tisoncik-Go, Jennifer

AU - Green, Richard R.

AU - Davis, Michael A.

AU - Dewey, Elyse C.

AU - Fairgrieve, Marian R.

AU - Gatenby, J. Christopher

AU - Richards, Todd

AU - Garden, Gwenn A.

AU - Diamond, Michael S.

AU - Juul, Sandra E.

AU - Grant, Richard F.

AU - Kuller, Larene

AU - Shaw, Dennis W.W.

AU - Ogle, Jason

AU - Gough, G. Michael

AU - Lee, Wonsok

AU - English, Chris

AU - Hevner, Robert F.

AU - Dobyns, William B.

AU - Gale, Michael

AU - Rajagopal, Lakshmi

PY - 2016/11/1

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N2 - We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

AB - We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

UR - https://www.scopus.com/pages/publications/84987677716

U2 - 10.1038/nm.4193

DO - 10.1038/nm.4193

M3 - Article

C2 - 27618651

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SN - 1078-8956

VL - 22

SP - 1256

EP - 1259

JO - Nature medicine

JF - Nature medicine

IS - 11

ER -

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

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