Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Kristina M. Adams Waldorf, Jennifer E. Stencel-Baerenwald, Raj P. Kapur, Colin Studholme, Erica Boldenow, Jay Vornhagen, Audrey Baldessari, Manjiri K. Dighe, Jeff Thiel, Sean Merillat, Blair Armistead, Jennifer Tisoncik-Go, Richard R. Green, Michael A. Davis, Elyse C. Dewey, Marian R. Fairgrieve, J. Christopher Gatenby, Todd Richards, Gwenn A. Garden, Michael S. DiamondSandra E. Juul, Richard F. Grant, Larene Kuller, Dennis W.W. Shaw, Jason Ogle, G. Michael Gough, Wonsok Lee, Chris English, Robert F. Hevner, William B. Dobyns, Michael Gale, Lakshmi Rajagopal

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

Original languageEnglish
Pages (from-to)1256-1259
Number of pages4
JournalNature medicine
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2016

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