Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina

Quan Chen, John W. Olney, Peter D. Lukasiewicz, Todd Almli, Carmelo Romano

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Three fenamates (flufenamate, meclofenamate and mefenamate) were examined for their protective effect on neurons under ischemic (glucose/oxygen deprivation) or excitotoxic conditions, using the isolated retina of chick embryo as a model. Retinal damage was evaluated by histology and lactate dehydrogenase assay. Whole-cell recording was used to examine the direct effect of the fenamates on glutamate receptor-mediated currents. The fenamates protected the retina against the ischemic or excitotoxic insult. Part of the neuroprotection by the fenamates derived from inhibition of N- methyl-D-aspartate receptor-mediated currents. However, kainate receptor- mediated currents were not blocked by the fenamates, which nonetheless reduced kainate receptor-mediated retinal damage. Our results raise the possibility that fenamates may serve as lead structures in the development of novel therapeutic agents against brain ischemia.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - Feb 20 1998


  • Excitotoxicity
  • Fenamate
  • Glutamate receptor
  • Ischemia
  • Kainate
  • N-Methyl-D-aspartate receptor
  • Retina


Dive into the research topics of 'Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina'. Together they form a unique fingerprint.

Cite this