Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

Vadim Grigura, Megan Barbier, Anna P. Zarov, Charles K. Kaufman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to 'tune' the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.

Original languageEnglish
Article number030726
JournalBiology Open
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Caloric restriction
  • Cancer models
  • Melanoma
  • Metabolism
  • Obesity

Fingerprint

Dive into the research topics of 'Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model'. Together they form a unique fingerprint.

Cite this