Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Yinghong Wang, Diana H. Wiesnoski, Beth A. Helmink, Vancheswaran Gopalakrishnan, Kati Choi, Hebert L. DuPont, Zhi Dong Jiang, Hamzah Abu-Sbeih, Christopher A. Sanchez, Chia Chi Chang, Edwin R. Parra, Alejandro Francisco-Cruz, Gottumukkala S. Raju, John R. Stroehlein, Matthew T. Campbell, Jianjun Gao, Sumit K. Subudhi, Dipen M. Maru, Jorge M. Blando, Alexander J. LazarJames P. Allison, Padmanee Sharma, Michael T. Tetzlaff, Jennifer A. Wargo, Robert R. Jenq

Research output: Contribution to journalArticlepeer-review

294 Scopus citations

Abstract

We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.

Original languageEnglish
Pages (from-to)1804-1808
Number of pages5
JournalNature medicine
Volume24
Issue number12
DOIs
StatePublished - Dec 1 2018

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