Features of skin-coincubated macrophages that promote recovery from spinal cord injury

Yonit Bomstein, Jonathan B. Marder, Karen Vitner, Igor Smirnov, Galit Lisaey, Oleg Butovsky, Valentin Fulga, Eti Yoles

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1β (IL-1β) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor α (TNF-α). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalJournal of Neuroimmunology
Volume142
Issue number1-2
DOIs
StatePublished - Sep 2003

Keywords

  • Central nervous system
  • Macrophage activation
  • Proinflammatory cytokines
  • Spinal cord injury
  • Syringomyelia

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