Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

IMPACC Network; IMPACC Steering Committee; Clinical & Data Coordinating Center (CDCC); IMPACC Data Analysis Group; IMPACC Site Investigators; IMPACC Core Laboratory; IMPACC Clinical Study Team; Al Ozonoff; Naresh Doni Jayavelu; Shanshan Liu; Esther Melamed; Carly E. Milliren; Jingjing Qi; Linda N. Geng; Grace A. McComsey; Charles B. Cairns; Lindsey R. Baden; Joanna Schaenman; Albert C. Shaw; Hady Samaha; Vicki Seyfert-Margolis; Florian Krammer; Lindsey B. Rosen; Hanno Steen; Caitlin Syphurs; Ravi Dandekar; Casey P. Shannon; Rafick P. Sekaly; Lauren I.R. Ehrlich; David B. Corry; Farrah Kheradmand; Mark A. Atkinson; Scott C. Brakenridge; Nelson I. Agudelo Higuita; Jordan P. Metcalf; Catherine L. Hough; William B. Messer; Bali Pulendran; Kari C. Nadeau; Mark M. Davis; Ana Fernandez Sesma; Viviana Simon; Harm van Bakel; Seunghee Kim-Schulze; David A. Hafler; Ofer Levy; Monica Kraft; Chris Bime; Elias K. Haddad; Carolyn S. Calfee; David J. Erle; Charles R. Langelier; Walter Eckalbar; Steven E. Bosinger; Bjoern Peters; Steven H. Kleinstein; Elaine F. Reed; Alison D. Augustine; Joann Diray-Arce; Holden T. Maecker; Matthew C. Altman; Ruth R. Montgomery; Patrice M. Becker; Nadine Rouphael; Kerry McEnaney; Brenda Barton; Claudia Lentucci; Mehmet Saluvan; Ana C. Chang; Annmarie Hoch; Marisa Albert; Tanzia Shaheen; Alvin T. Kho; Sanya Thomas; Jing Chen; Maimouna D. Murphy; Mitchell Cooney; Arash Nemati Hayati; Robert Bryant; James Abraham; Scott Presnell; Tomasz Jancsyk; Cole Maguire; Brian Lee; Slim Fourati; Denise A. Esserman; Leying Guan; Jeremy Gygi; Shrikant Pawar; Anderson Brito; Gabriela K. Fragiadakis; Ravi Patel; Scott J. Tebbutt; James A. Overton; Randi Vita; Kerstin Westendorf; Rama V. Thyagarajan; Justin F. Rousseau; Dennis Wylie; Todd A. Triplett; Erna Kojic; Sharon Chinthrajah; Neera Ahuja; Angela J. Rogers; Maja Artandi; George Yendewa; Debra L. Powell; James N. Kim; Brent Simmons; I. Michael Goonewardene; Cecilia M. Smith; Mark Martens; Amy C. Sherman; Stephen R. Walsh; Nicolas C. Issa; Ramin Salehi-Rad; Charles Dela Cruz; Shelli Farhadian; Akiko Iwasaki; Albert I. Ko; Evan J. Anderson; Aneesh K. Mehta; Jonathan E. Sevransky; Aleksandra Leligdowicz; Michael A. Matthay; Jonathan P. Singer; Kirsten N. Kangelaris; Carolyn M. Hendrickson; Matthew F. Krummel; Prescott G. Woodruff; Matthew L. Anderson; Faheem W. Guirgis; Douglas A. Drevets; Brent R. Brown; Sarah A.R. Siegel; Zhengchun Lu; Jarrod Mosier; Hiroki Kimura; Bernard Khor; Adeeb Rahman; Daniel Stadlbauer; Jayeeta Dutta; Ana Silvia Gonzalez-Reiche; Adriana Van de Guchte; Juan Manuel Carreño; Gagandeep Singh; Ariel Raskin; Johnstone Tcheou; Dominika Bielak; Hisaaki Kawabata; Hui Xie; Geoffrey Kelly; Manishkumar Patel; Kai Nie; Temima Yellin; Miriam Fried; Leeba Sullivan; Sara Morris; Scott Sieg; Patrick van Zalm; Benoit Fatou; Kevin Mendez; Jessica Lasky-Su; Scott R. Hutton; Greg Michelotti; Kari Wong; Meenakshi Jha; Arthur Viode; Naama Kanarek; Boryana Petrova; Yujiao Zhao; Arun K. Boddapati; Greg K. Tharp; Kathryn L. Pellegrini; Elizabeth Beagle; David Cowan; Sydney Hamilton; Susan Pereira Ribeiro; Thomas Hodder; Serena Lee; Michael R. Wilson; Bonny Alvarenga; Jayant Rajan; Andreww Schroeder; Alexandra Tsitsiklis; Eran Mick; Yanedth Sanchez Guerrero; Christina Love; Lenka Maliskova; Michael Adkisson; Nadia Siles; Janelle Geltman; Kerin Hurley; Miti Saksena; Deena Altman; Komal Srivastava; Lily Q. Eaker; Maria C. Bermúdez-González; Katherine F. Beach; Levy A. Sominsky; Arman R. Azad; Lubbertus C.F. Mulder; Giulio Kleiner; Alexandra S. Lee; Evan Do; Andrea Fernandes; Pratik Sinha

doi:10.1038/s41467-023-44090-5

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

IMPACC Network, IMPACC Steering Committee, Clinical & Data Coordinating Center (CDCC), IMPACC Data Analysis Group, IMPACC Site Investigators, IMPACC Core Laboratory, IMPACC Clinical Study Team, Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E. Milliren, Jingjing Qi, Linda N. Geng, Grace A. McComsey, Charles B. Cairns, Lindsey R. Baden, Joanna Schaenman, Albert C. Shaw, Hady SamahaVicki Seyfert-Margolis, Florian Krammer, Lindsey B. Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P. Shannon, Rafick P. Sekaly, Lauren I.R. Ehrlich, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernandez Sesma, Viviana Simon, Harm van Bakel, Seunghee Kim-Schulze, David A. Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K. Haddad, Carolyn S. Calfee, David J. Erle, Charles R. Langelier, Walter Eckalbar, Steven E. Bosinger, Bjoern Peters, Steven H. Kleinstein, Elaine F. Reed, Alison D. Augustine, Joann Diray-Arce, Holden T. Maecker, Matthew C. Altman, Ruth R. Montgomery, Patrice M. Becker, Nadine Rouphael, Kerry McEnaney, Brenda Barton, Claudia Lentucci, Mehmet Saluvan, Ana C. Chang, Annmarie Hoch, Marisa Albert, Tanzia Shaheen, Alvin T. Kho, Sanya Thomas, Jing Chen, Maimouna D. Murphy, Mitchell Cooney, Arash Nemati Hayati, Robert Bryant, James Abraham, Scott Presnell, Tomasz Jancsyk, Cole Maguire, Brian Lee, Slim Fourati, Denise A. Esserman, Leying Guan, Jeremy Gygi, Shrikant Pawar, Anderson Brito, Gabriela K. Fragiadakis, Ravi Patel, Scott J. Tebbutt, James A. Overton, Randi Vita, Kerstin Westendorf, Rama V. Thyagarajan, Justin F. Rousseau, Dennis Wylie, Todd A. Triplett, Erna Kojic, Sharon Chinthrajah, Neera Ahuja, Angela J. Rogers, Maja Artandi, George Yendewa, Debra L. Powell, James N. Kim, Brent Simmons, I. Michael Goonewardene, Cecilia M. Smith, Mark Martens, Amy C. Sherman, Stephen R. Walsh, Nicolas C. Issa, Ramin Salehi-Rad, Charles Dela Cruz, Shelli Farhadian, Akiko Iwasaki, Albert I. Ko, Evan J. Anderson, Aneesh K. Mehta, Jonathan E. Sevransky, Aleksandra Leligdowicz, Michael A. Matthay, Jonathan P. Singer, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Matthew F. Krummel, Prescott G. Woodruff, Matthew L. Anderson, Faheem W. Guirgis, Douglas A. Drevets, Brent R. Brown, Sarah A.R. Siegel, Zhengchun Lu, Jarrod Mosier, Hiroki Kimura, Bernard Khor, Adeeb Rahman, Daniel Stadlbauer, Jayeeta Dutta, Ana Silvia Gonzalez-Reiche, Adriana Van de Guchte, Juan Manuel Carreño, Gagandeep Singh, Ariel Raskin, Johnstone Tcheou, Dominika Bielak, Hisaaki Kawabata, Hui Xie, Geoffrey Kelly, Manishkumar Patel, Kai Nie, Temima Yellin, Miriam Fried, Leeba Sullivan, Sara Morris, Scott Sieg, Patrick van Zalm, Benoit Fatou, Kevin Mendez, Jessica Lasky-Su, Scott R. Hutton, Greg Michelotti, Kari Wong, Meenakshi Jha, Arthur Viode, Naama Kanarek, Boryana Petrova, Yujiao Zhao, Arun K. Boddapati, Greg K. Tharp, Kathryn L. Pellegrini, Elizabeth Beagle, David Cowan, Sydney Hamilton, Susan Pereira Ribeiro, Thomas Hodder, Serena Lee, Michael R. Wilson, Bonny Alvarenga, Jayant Rajan, Andreww Schroeder, Alexandra Tsitsiklis, Eran Mick, Yanedth Sanchez Guerrero, Christina Love, Lenka Maliskova, Michael Adkisson, Nadia Siles, Janelle Geltman, Kerin Hurley, Miti Saksena, Deena Altman, Komal Srivastava, Lily Q. Eaker, Maria C. Bermúdez-González, Katherine F. Beach, Levy A. Sominsky, Arman R. Azad, Lubbertus C.F. Mulder, Giulio Kleiner, Alexandra S. Lee, Evan Do, Andrea Fernandes, Pratik Sinha

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

Original language	English
Article number	216
Journal	Nature communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-023-44090-5
State	Published - Jan 2024

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10.1038/s41467-023-44090-5

Cite this

IMPACC Network, IMPACC Steering Committee, Clinical & Data Coordinating Center (CDCC), IMPACC Data Analysis Group, IMPACC Site Investigators, IMPACC Core Laboratory, IMPACC Clinical Study Team, Ozonoff, A., Jayavelu, N. D., Liu, S., Melamed, E., Milliren, C. E., Qi, J., Geng, L. N., McComsey, G. A., Cairns, C. B., Baden, L. R., Schaenman, J., Shaw, A. C., ... Sinha, P. (2024). Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nature communications, 15(1), Article 216. https://doi.org/10.1038/s41467-023-44090-5

@article{489e66cc7e5942b1a871364c15d0e78a,

title = "Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study",

abstract = "Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.",

author = "{IMPACC Network} and {IMPACC Steering Committee} and {Clinical & Data Coordinating Center (CDCC)} and {IMPACC Data Analysis Group} and {IMPACC Site Investigators} and {IMPACC Core Laboratory} and {IMPACC Clinical Study Team} and Al Ozonoff and Jayavelu, {Naresh Doni} and Shanshan Liu and Esther Melamed and Milliren, {Carly E.} and Jingjing Qi and Geng, {Linda N.} and McComsey, {Grace A.} and Cairns, {Charles B.} and Baden, {Lindsey R.} and Joanna Schaenman and Shaw, {Albert C.} and Hady Samaha and Vicki Seyfert-Margolis and Florian Krammer and Rosen, {Lindsey B.} and Hanno Steen and Caitlin Syphurs and Ravi Dandekar and Shannon, {Casey P.} and Sekaly, {Rafick P.} and Ehrlich, {Lauren I.R.} and Corry, {David B.} and Farrah Kheradmand and Atkinson, {Mark A.} and Brakenridge, {Scott C.} and {Agudelo Higuita}, {Nelson I.} and Metcalf, {Jordan P.} and Hough, {Catherine L.} and Messer, {William B.} and Bali Pulendran and Nadeau, {Kari C.} and Davis, {Mark M.} and Sesma, {Ana Fernandez} and Viviana Simon and {van Bakel}, Harm and Seunghee Kim-Schulze and Hafler, {David A.} and Ofer Levy and Monica Kraft and Chris Bime and Haddad, {Elias K.} and Calfee, {Carolyn S.} and Erle, {David J.} and Langelier, {Charles R.} and Walter Eckalbar and Bosinger, {Steven E.} and Bjoern Peters and Kleinstein, {Steven H.} and Reed, {Elaine F.} and Augustine, {Alison D.} and Joann Diray-Arce and Maecker, {Holden T.} and Altman, {Matthew C.} and Montgomery, {Ruth R.} and Becker, {Patrice M.} and Nadine Rouphael and Kerry McEnaney and Brenda Barton and Claudia Lentucci and Mehmet Saluvan and Chang, {Ana C.} and Annmarie Hoch and Marisa Albert and Tanzia Shaheen and Kho, {Alvin T.} and Sanya Thomas and Jing Chen and Murphy, {Maimouna D.} and Mitchell Cooney and Hayati, {Arash Nemati} and Robert Bryant and James Abraham and Scott Presnell and Tomasz Jancsyk and Cole Maguire and Brian Lee and Slim Fourati and Esserman, {Denise A.} and Leying Guan and Jeremy Gygi and Shrikant Pawar and Anderson Brito and Fragiadakis, {Gabriela K.} and Ravi Patel and Tebbutt, {Scott J.} and Overton, {James A.} and Randi Vita and Kerstin Westendorf and Thyagarajan, {Rama V.} and Rousseau, {Justin F.} and Dennis Wylie and Triplett, {Todd A.} and Erna Kojic and Sharon Chinthrajah and Neera Ahuja and Rogers, {Angela J.} and Maja Artandi and George Yendewa and Powell, {Debra L.} and Kim, {James N.} and Brent Simmons and {Michael Goonewardene}, I. and Smith, {Cecilia M.} and Mark Martens and Sherman, {Amy C.} and Walsh, {Stephen R.} and Issa, {Nicolas C.} and Ramin Salehi-Rad and {Dela Cruz}, Charles and Shelli Farhadian and Akiko Iwasaki and Ko, {Albert I.} and Anderson, {Evan J.} and Mehta, {Aneesh K.} and Sevransky, {Jonathan E.} and Aleksandra Leligdowicz and Matthay, {Michael A.} and Singer, {Jonathan P.} and Kangelaris, {Kirsten N.} and Hendrickson, {Carolyn M.} and Krummel, {Matthew F.} and Woodruff, {Prescott G.} and Anderson, {Matthew L.} and Guirgis, {Faheem W.} and Drevets, {Douglas A.} and Brown, {Brent R.} and Siegel, {Sarah A.R.} and Zhengchun Lu and Jarrod Mosier and Hiroki Kimura and Bernard Khor and Adeeb Rahman and Daniel Stadlbauer and Jayeeta Dutta and Gonzalez-Reiche, {Ana Silvia} and {Van de Guchte}, Adriana and Carre{\~n}o, {Juan Manuel} and Gagandeep Singh and Ariel Raskin and Johnstone Tcheou and Dominika Bielak and Hisaaki Kawabata and Hui Xie and Geoffrey Kelly and Manishkumar Patel and Kai Nie and Temima Yellin and Miriam Fried and Leeba Sullivan and Sara Morris and Scott Sieg and {van Zalm}, Patrick and Benoit Fatou and Kevin Mendez and Jessica Lasky-Su and Hutton, {Scott R.} and Greg Michelotti and Kari Wong and Meenakshi Jha and Arthur Viode and Naama Kanarek and Boryana Petrova and Yujiao Zhao and Boddapati, {Arun K.} and Tharp, {Greg K.} and Pellegrini, {Kathryn L.} and Elizabeth Beagle and David Cowan and Sydney Hamilton and Ribeiro, {Susan Pereira} and Thomas Hodder and Serena Lee and Wilson, {Michael R.} and Bonny Alvarenga and Jayant Rajan and Andreww Schroeder and Alexandra Tsitsiklis and Eran Mick and Guerrero, {Yanedth Sanchez} and Christina Love and Lenka Maliskova and Michael Adkisson and Nadia Siles and Janelle Geltman and Kerin Hurley and Miti Saksena and Deena Altman and Komal Srivastava and Eaker, {Lily Q.} and Berm{\'u}dez-Gonz{\'a}lez, {Maria C.} and Beach, {Katherine F.} and Sominsky, {Levy A.} and Azad, {Arman R.} and Mulder, {Lubbertus C.F.} and Giulio Kleiner and Lee, {Alexandra S.} and Evan Do and Andrea Fernandes and Pratik Sinha",

note = "Publisher Copyright: {\textcopyright} 2024, The Author(s).",

year = "2024",

month = jan,

doi = "10.1038/s41467-023-44090-5",

language = "English",

volume = "15",

journal = "Nature communications",

issn = "2041-1723",

number = "1",

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IMPACC Network, IMPACC Steering Committee, Clinical & Data Coordinating Center (CDCC), IMPACC Data Analysis Group, IMPACC Site Investigators, IMPACC Core Laboratory, IMPACC Clinical Study Team, Ozonoff, A, Jayavelu, ND, Liu, S, Melamed, E, Milliren, CE, Qi, J, Geng, LN, McComsey, GA, Cairns, CB, Baden, LR, Schaenman, J, Shaw, AC, Samaha, H, Seyfert-Margolis, V, Krammer, F, Rosen, LB, Steen, H, Syphurs, C, Dandekar, R, Shannon, CP, Sekaly, RP, Ehrlich, LIR, Corry, DB, Kheradmand, F, Atkinson, MA, Brakenridge, SC, Agudelo Higuita, NI, Metcalf, JP, Hough, CL, Messer, WB, Pulendran, B, Nadeau, KC, Davis, MM, Sesma, AF, Simon, V, van Bakel, H, Kim-Schulze, S, Hafler, DA, Levy, O, Kraft, M, Bime, C, Haddad, EK, Calfee, CS, Erle, DJ, Langelier, CR, Eckalbar, W, Bosinger, SE, Peters, B, Kleinstein, SH, Reed, EF, Augustine, AD, Diray-Arce, J, Maecker, HT, Altman, MC, Montgomery, RR, Becker, PM, Rouphael, N, McEnaney, K, Barton, B, Lentucci, C, Saluvan, M, Chang, AC, Hoch, A, Albert, M, Shaheen, T, Kho, AT, Thomas, S, Chen, J, Murphy, MD, Cooney, M, Hayati, AN, Bryant, R, Abraham, J, Presnell, S, Jancsyk, T, Maguire, C, Lee, B, Fourati, S, Esserman, DA, Guan, L, Gygi, J, Pawar, S, Brito, A, Fragiadakis, GK, Patel, R, Tebbutt, SJ, Overton, JA, Vita, R, Westendorf, K, Thyagarajan, RV, Rousseau, JF, Wylie, D, Triplett, TA, Kojic, E, Chinthrajah, S, Ahuja, N, Rogers, AJ, Artandi, M, Yendewa, G, Powell, DL, Kim, JN, Simmons, B, Michael Goonewardene, I, Smith, CM, Martens, M, Sherman, AC, Walsh, SR, Issa, NC, Salehi-Rad, R, Dela Cruz, C, Farhadian, S, Iwasaki, A, Ko, AI, Anderson, EJ, Mehta, AK, Sevransky, JE, Leligdowicz, A, Matthay, MA, Singer, JP, Kangelaris, KN, Hendrickson, CM, Krummel, MF, Woodruff, PG, Anderson, ML, Guirgis, FW, Drevets, DA, Brown, BR, Siegel, SAR, Lu, Z, Mosier, J, Kimura, H, Khor, B, Rahman, A, Stadlbauer, D, Dutta, J, Gonzalez-Reiche, AS, Van de Guchte, A, Carreño, JM, Singh, G, Raskin, A, Tcheou, J, Bielak, D, Kawabata, H, Xie, H, Kelly, G, Patel, M, Nie, K, Yellin, T, Fried, M, Sullivan, L, Morris, S, Sieg, S, van Zalm, P, Fatou, B, Mendez, K, Lasky-Su, J, Hutton, SR, Michelotti, G, Wong, K, Jha, M, Viode, A, Kanarek, N, Petrova, B, Zhao, Y, Boddapati, AK, Tharp, GK, Pellegrini, KL, Beagle, E, Cowan, D, Hamilton, S, Ribeiro, SP, Hodder, T, Lee, S, Wilson, MR, Alvarenga, B, Rajan, J, Schroeder, A, Tsitsiklis, A, Mick, E, Guerrero, YS, Love, C, Maliskova, L, Adkisson, M, Siles, N, Geltman, J, Hurley, K, Saksena, M, Altman, D, Srivastava, K, Eaker, LQ, Bermúdez-González, MC, Beach, KF, Sominsky, LA, Azad, AR, Mulder, LCF, Kleiner, G, Lee, AS, Do, E, Fernandes, A & Sinha, P 2024, 'Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study', Nature communications, vol. 15, no. 1, 216. https://doi.org/10.1038/s41467-023-44090-5

TY - JOUR

T1 - Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes

T2 - results from the IMPACC study

AU - IMPACC Network

AU - IMPACC Steering Committee

AU - Clinical & Data Coordinating Center (CDCC)

AU - IMPACC Data Analysis Group

AU - IMPACC Site Investigators

AU - IMPACC Core Laboratory

AU - IMPACC Clinical Study Team

AU - Ozonoff, Al

AU - Jayavelu, Naresh Doni

AU - Liu, Shanshan

AU - Melamed, Esther

AU - Milliren, Carly E.

AU - Qi, Jingjing

AU - Geng, Linda N.

AU - McComsey, Grace A.

AU - Cairns, Charles B.

AU - Baden, Lindsey R.

AU - Schaenman, Joanna

AU - Shaw, Albert C.

AU - Samaha, Hady

AU - Seyfert-Margolis, Vicki

AU - Krammer, Florian

AU - Rosen, Lindsey B.

AU - Steen, Hanno

AU - Syphurs, Caitlin

AU - Dandekar, Ravi

AU - Shannon, Casey P.

AU - Sekaly, Rafick P.

AU - Ehrlich, Lauren I.R.

AU - Corry, David B.

AU - Kheradmand, Farrah

AU - Atkinson, Mark A.

AU - Brakenridge, Scott C.

AU - Agudelo Higuita, Nelson I.

AU - Metcalf, Jordan P.

AU - Hough, Catherine L.

AU - Messer, William B.

AU - Pulendran, Bali

AU - Nadeau, Kari C.

AU - Davis, Mark M.

AU - Sesma, Ana Fernandez

AU - Simon, Viviana

AU - van Bakel, Harm

AU - Kim-Schulze, Seunghee

AU - Hafler, David A.

AU - Levy, Ofer

AU - Kraft, Monica

AU - Bime, Chris

AU - Haddad, Elias K.

AU - Calfee, Carolyn S.

AU - Erle, David J.

AU - Langelier, Charles R.

AU - Eckalbar, Walter

AU - Bosinger, Steven E.

AU - Peters, Bjoern

AU - Kleinstein, Steven H.

AU - Reed, Elaine F.

AU - Augustine, Alison D.

AU - Diray-Arce, Joann

AU - Maecker, Holden T.

AU - Altman, Matthew C.

AU - Montgomery, Ruth R.

AU - Becker, Patrice M.

AU - Rouphael, Nadine

AU - McEnaney, Kerry

AU - Barton, Brenda

AU - Lentucci, Claudia

AU - Saluvan, Mehmet

AU - Chang, Ana C.

AU - Hoch, Annmarie

AU - Albert, Marisa

AU - Shaheen, Tanzia

AU - Kho, Alvin T.

AU - Thomas, Sanya

AU - Chen, Jing

AU - Murphy, Maimouna D.

AU - Cooney, Mitchell

AU - Hayati, Arash Nemati

AU - Bryant, Robert

AU - Abraham, James

AU - Presnell, Scott

AU - Jancsyk, Tomasz

AU - Maguire, Cole

AU - Lee, Brian

AU - Fourati, Slim

AU - Esserman, Denise A.

AU - Guan, Leying

AU - Gygi, Jeremy

AU - Pawar, Shrikant

AU - Brito, Anderson

AU - Fragiadakis, Gabriela K.

AU - Patel, Ravi

AU - Tebbutt, Scott J.

AU - Overton, James A.

AU - Vita, Randi

AU - Westendorf, Kerstin

AU - Thyagarajan, Rama V.

AU - Rousseau, Justin F.

AU - Wylie, Dennis

AU - Triplett, Todd A.

AU - Kojic, Erna

AU - Chinthrajah, Sharon

AU - Ahuja, Neera

AU - Rogers, Angela J.

AU - Artandi, Maja

AU - Yendewa, George

AU - Powell, Debra L.

AU - Kim, James N.

AU - Simmons, Brent

AU - Michael Goonewardene, I.

AU - Smith, Cecilia M.

AU - Martens, Mark

AU - Sherman, Amy C.

AU - Walsh, Stephen R.

AU - Issa, Nicolas C.

AU - Salehi-Rad, Ramin

AU - Dela Cruz, Charles

AU - Farhadian, Shelli

AU - Iwasaki, Akiko

AU - Ko, Albert I.

AU - Anderson, Evan J.

AU - Mehta, Aneesh K.

AU - Sevransky, Jonathan E.

AU - Leligdowicz, Aleksandra

AU - Matthay, Michael A.

AU - Singer, Jonathan P.

AU - Kangelaris, Kirsten N.

AU - Hendrickson, Carolyn M.

AU - Krummel, Matthew F.

AU - Woodruff, Prescott G.

AU - Anderson, Matthew L.

AU - Guirgis, Faheem W.

AU - Drevets, Douglas A.

AU - Brown, Brent R.

AU - Siegel, Sarah A.R.

AU - Lu, Zhengchun

AU - Mosier, Jarrod

AU - Kimura, Hiroki

AU - Khor, Bernard

AU - Rahman, Adeeb

AU - Stadlbauer, Daniel

AU - Dutta, Jayeeta

AU - Gonzalez-Reiche, Ana Silvia

AU - Van de Guchte, Adriana

AU - Carreño, Juan Manuel

AU - Singh, Gagandeep

AU - Raskin, Ariel

AU - Tcheou, Johnstone

AU - Bielak, Dominika

AU - Kawabata, Hisaaki

AU - Xie, Hui

AU - Kelly, Geoffrey

AU - Patel, Manishkumar

AU - Nie, Kai

AU - Yellin, Temima

AU - Fried, Miriam

AU - Sullivan, Leeba

AU - Morris, Sara

AU - Sieg, Scott

AU - van Zalm, Patrick

AU - Fatou, Benoit

AU - Mendez, Kevin

AU - Lasky-Su, Jessica

AU - Hutton, Scott R.

AU - Michelotti, Greg

AU - Wong, Kari

AU - Jha, Meenakshi

AU - Viode, Arthur

AU - Kanarek, Naama

AU - Petrova, Boryana

AU - Zhao, Yujiao

AU - Boddapati, Arun K.

AU - Tharp, Greg K.

AU - Pellegrini, Kathryn L.

AU - Beagle, Elizabeth

AU - Cowan, David

AU - Hamilton, Sydney

AU - Ribeiro, Susan Pereira

AU - Hodder, Thomas

AU - Lee, Serena

AU - Wilson, Michael R.

AU - Alvarenga, Bonny

AU - Rajan, Jayant

AU - Schroeder, Andreww

AU - Tsitsiklis, Alexandra

AU - Mick, Eran

AU - Guerrero, Yanedth Sanchez

AU - Love, Christina

AU - Maliskova, Lenka

AU - Adkisson, Michael

AU - Siles, Nadia

AU - Geltman, Janelle

AU - Hurley, Kerin

AU - Saksena, Miti

AU - Altman, Deena

AU - Srivastava, Komal

AU - Eaker, Lily Q.

AU - Bermúdez-González, Maria C.

AU - Beach, Katherine F.

AU - Sominsky, Levy A.

AU - Azad, Arman R.

AU - Mulder, Lubbertus C.F.

AU - Kleiner, Giulio

AU - Lee, Alexandra S.

AU - Do, Evan

AU - Fernandes, Andrea

AU - Sinha, Pratik

PY - 2024/1

Y1 - 2024/1

N2 - Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

AB - Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

UR - http://www.scopus.com/inward/record.url?scp=85181510888&partnerID=8YFLogxK

U2 - 10.1038/s41467-023-44090-5

DO - 10.1038/s41467-023-44090-5

M3 - Article

C2 - 38172101

AN - SCOPUS:85181510888

SN - 2041-1723

VL - 15

JO - Nature communications

JF - Nature communications

IS - 1

M1 - 216

ER -

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

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