Feasibility of isotope harvesting at a projectile fragmentation facility: 67Cu

Tara Mastren; Aranh Pen; Graham F. Peaslee; Nick Wozniak; Shaun Loveless; Scott Essenmacher; Lee G. Sobotka; David J. Morrissey; Suzanne E. Lapi

doi:10.1038/srep06706

Feasibility of isotope harvesting at a projectile fragmentation facility: ⁶⁷Cu

Tara Mastren, Aranh Pen, Graham F. Peaslee, Nick Wozniak, Shaun Loveless, Scott Essenmacher, Lee G. Sobotka, David J. Morrissey, Suzanne E. Lapi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The work presented here describes a proof-of-principle experiment for the chemical extraction of ⁶⁷Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A ⁶⁷Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88±3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.

Original language	English
Article number	6706
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep06706
State	Published - Oct 21 2014

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abstract = "The work presented here describes a proof-of-principle experiment for the chemical extraction of 67Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A 67Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88±3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.",

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AU - Mastren, Tara

AU - Pen, Aranh

AU - Peaslee, Graham F.

AU - Wozniak, Nick

AU - Loveless, Shaun

AU - Essenmacher, Scott

AU - Sobotka, Lee G.

AU - Morrissey, David J.

AU - Lapi, Suzanne E.

PY - 2014/10/21

Y1 - 2014/10/21

N2 - The work presented here describes a proof-of-principle experiment for the chemical extraction of 67Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A 67Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88±3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.

AB - The work presented here describes a proof-of-principle experiment for the chemical extraction of 67Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A 67Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88±3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.

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Feasibility of isotope harvesting at a projectile fragmentation facility: ⁶⁷Cu

Abstract

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