Feasibility and Outcomes of an Exercise Intervention for Chemotherapy-Induced Heart Failure

Edward Tsai, Elie Mouhayar, Daniel Lenihan, Jaejoon Song, Jean Bernard Durand, Anecita Fadol, Mona Massey, Carol Harrison, Karen Basen-Engquist

Research output: Contribution to journalArticle

1 Scopus citations


Cancer treatment-related heart failure (HF) is an emerging health concern, as the number of survivors is increasing rapidly, and cardiac health issues are a leading cause of mortality in this population. While there is general evidence for the efficacy of exercise rehabilitation interventions, more research is needed on exercise rehabilitation interventions for patients specifically with treatment-induced HF and whether such interventions are safe and well-accepted. This study provides feasibility and health outcomes of a pilot exercise intervention for cancer survivors with chemotherapy-induced HF. Methods: Twenty-five participants were randomized to a clinic-based exercise intervention or a wait-list control group or, alternatively, allowed to enroll in a home-based exercise intervention if they declined the randomized study. For purposes of analysis, both types of exercise programs were combined into a single intervention group. Repeated-measures analysis of variance was conducted to assess for significant time and treatment group main effects separately and time × treatment group interaction effects. Results: Significant improvements in maximum oxygen uptake (o2max) were observed in the intervention group. Intervention satisfaction and adherence were high for both clinic- and home-based interventions, with no reported serious adverse events. Enrollment was initially low for the clinic-based intervention, necessitating the addition of the home-based program as an intervention alternative. Conclusions: Results suggest that exercise rehabilitation interventions are feasible in terms of safety, retention, and satisfaction and have the potential to improve o2max. To maximize adherence and benefits while minimizing participant burden, an ideal intervention may incorporate elements of both clinic-based supervised exercise sessions and a home-based program.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Issue number3
StatePublished - May 1 2019


  • cancer
  • exercise
  • feasibility
  • heart failure
  • intervention

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