FDG-PET in two cases of neurofibromatosis type 1 and atypical malignancies

P. de Blank, K. Cole, L. Kersun, A. Green, J. J. Wilkes, J. Belasco, R. Bagatell, L. C. Bailey, M. J. Fisher

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Abstract

Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although 18F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours.

Original languageEnglish
Pages (from-to)e345-e348
JournalCurrent Oncology
Volume21
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Germ-cell tumours
  • Hodgkin lymphoma
  • Klinefelter syndrome
  • Neurofibromatosis type 1
  • Pediatric oncology

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