Fatty Liver Disease

Dina G. Tiniakos, Quentin M. Anstee, Elizabeth M. Brunt, Alastair D. Burt

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Fatty liver disease (FLD) has a wide histopathology spectrum including simple steatosis, steatohepatitis with or without fibrosis, and cirrhosis that may be complicated by hepatocellular carcinoma (HCC). The two main entities that comprise FLD, alcohol-related liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) associated to metabolic dysfunction, have both similarities and differences. In this chapter, some of the features that are common to both are considered, followed by a review of the pathogenetic and pathological features of each and discussion on how the two can be distinguished clinically and histopathologically. NAFLD concurrent with other liver disease, NAFLD in other clinical settings and treatment options are also discussed.

Original languageEnglish
Title of host publicationMacSween's Pathology of the Liver, Eighth Edition
Number of pages72
ISBN (Electronic)9780702082283
ISBN (Print)9780702082290
StatePublished - Jan 1 2023


  • alcohol-related
  • alcoholic
  • diabetes
  • fatty liver
  • metabolic syndrome.
  • nonalcoholic
  • obesity
  • steatohepatitis
  • steatosis


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