TY - JOUR
T1 - Fatty Acid Transport and Signaling
T2 - Mechanisms and Physiological Implications
AU - Samovski, Dmitri
AU - Jacome-Sosa, Miriam
AU - Abumrad, Nada A.
N1 - Funding Information:
This work was supported by the US National Institutes of Health (NIH) grants DK060022 (N.A.A.) and HL045095 (N.A.A.), and a pilot and feasibility award (M.J.S.) from the Nutrition and Obesity Research Center at Washington University School of Medicine (P30 DK056341). The authors gratefully acknowledge the contribution of Vivek Peche and Terri Pietka to some of the work discussed in this review.
Publisher Copyright:
Copyright © 2023 by the author(s).
PY - 2023/2/10
Y1 - 2023/2/10
N2 - Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel source and also serve as metabolic regulators through FA signaling mediated by membrane FA receptors. Impaired tissue FA uptake has been linked to major complications of obesity, including insulin resistance, cardiovascular disease, and type 2 diabetes. Fatty acid interactions with a membrane receptor and the initiation of signaling can modify pathways related to nutrient uptake and processing, cell proliferation or differentiation, and secretion of bioactive factors. Here, we review the major membrane receptors involved in FA uptake and FA signaling. We focus on two types of membrane receptors for long-chain FAs: CD36 and the G protein-coupled FA receptors FFAR1 and FFAR4. We describe key signaling pathways and metabolic outcomes for CD36, FFAR1, and FFAR4 and highlight the parallels that provide insight into FA regulation of cell function.
AB - Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel source and also serve as metabolic regulators through FA signaling mediated by membrane FA receptors. Impaired tissue FA uptake has been linked to major complications of obesity, including insulin resistance, cardiovascular disease, and type 2 diabetes. Fatty acid interactions with a membrane receptor and the initiation of signaling can modify pathways related to nutrient uptake and processing, cell proliferation or differentiation, and secretion of bioactive factors. Here, we review the major membrane receptors involved in FA uptake and FA signaling. We focus on two types of membrane receptors for long-chain FAs: CD36 and the G protein-coupled FA receptors FFAR1 and FFAR4. We describe key signaling pathways and metabolic outcomes for CD36, FFAR1, and FFAR4 and highlight the parallels that provide insight into FA regulation of cell function.
KW - CD36
KW - FFAR1
KW - FFAR4
KW - caveolin
KW - fatty acid signaling
KW - tissue repair
KW - β-oxidation
UR - http://www.scopus.com/inward/record.url?scp=85147892732&partnerID=8YFLogxK
U2 - 10.1146/annurev-physiol-032122-030352
DO - 10.1146/annurev-physiol-032122-030352
M3 - Review article
C2 - 36347219
AN - SCOPUS:85147892732
SN - 0066-4278
VL - 85
SP - 317
EP - 337
JO - Annual Review of Physiology
JF - Annual Review of Physiology
ER -