TY - JOUR
T1 - Fatty acid synthase and liver triglyceride metabolism
T2 - Housekeeper or messenger?
AU - Jensen-Urstad, Anne P.L.
AU - Semenkovich, Clay F.
PY - 2012/5
Y1 - 2012/5
N2 - Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has long been categorized as a housekeeping protein, producing fat for storage of energy when nutrients are present in excess. Most previous studies of FAS regulation have focused on the control of gene expression. However, recent findings suggest that hepatic FAS may also be involved in signaling processes that include activation of peroxisome proliferator-activated receptor α (PPARα). Moreover, reports of rapid alterations in FAS activity as well as findings of post-translational modifications of the FAS protein support the notion that dynamic events in addition to transcription impact FAS regulation. These results indicate that FAS enzyme activity can impact liver physiology through signaling as well as energy storage and that its regulation may be complex. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease.
AB - Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has long been categorized as a housekeeping protein, producing fat for storage of energy when nutrients are present in excess. Most previous studies of FAS regulation have focused on the control of gene expression. However, recent findings suggest that hepatic FAS may also be involved in signaling processes that include activation of peroxisome proliferator-activated receptor α (PPARα). Moreover, reports of rapid alterations in FAS activity as well as findings of post-translational modifications of the FAS protein support the notion that dynamic events in addition to transcription impact FAS regulation. These results indicate that FAS enzyme activity can impact liver physiology through signaling as well as energy storage and that its regulation may be complex. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease.
KW - Diabetes
KW - Fatty liver
KW - Lipid signaling
KW - Obesity
KW - PPARα
KW - Post-translational regulation
UR - http://www.scopus.com/inward/record.url?scp=84859161710&partnerID=8YFLogxK
U2 - 10.1016/j.bbalip.2011.09.017
DO - 10.1016/j.bbalip.2011.09.017
M3 - Review article
C2 - 22009142
AN - SCOPUS:84859161710
VL - 1821
SP - 747
EP - 753
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
SN - 1388-1981
IS - 5
ER -