TY - JOUR
T1 - Fatty acid kinetic responses to exercise
T2 - Effects of obesity, body fat distribution, and energy-restricted diet
AU - Kanaley, Jill A.
AU - Cryer, Philip E.
AU - Jensen, Michael D.
PY - 1993/7
Y1 - 1993/7
N2 - Upper body obesity (UB Ob) is associated with a reduced net free fatty acid (FFA) response to epinephrine compared with nonobese (Non Ob) and lower-body obese (LB Ob) women. Because catecholamines regulate some of the metabolic responses to exercise, we hypothesized that UB Ob would have a reduced net FFA response to exercise. Plasma FFA rate of appearance (Ra) ([1-14C]palnutate) and fatty acid oxidation (indirect calorimetry) were therefore measured during 2.5 h of stationary bicycle exercise (45% V̇O2 peak) in 13 UB Ob, 11 LB Ob, and 8 Non Ob premenopausal women. 10 UB Ob and 8 LB Ob women were retested after an ∼ 8-kg weight loss. Results: During exercise Non Ob and LB Ob women had greater increments in FFA availability (51±7 and 53±8 mmol, respectively) than UB Ob women (27±4 mmol, P < 0.05). Total exercise FFA availability and fatty acid oxidation were not different between Non Ob, LB Ob, and UB Ob women, however. Following weight loss (∼ 8 kg), the FFA response to exercise increased (P < 0.01) and remained greater (P < 0.05) in LB Ob than in UB Ob women. In conclusion, the FFA response to exercise was reduced in UB Ob women before and after weight loss, but no effects on fatty acid oxidation were apparent.
AB - Upper body obesity (UB Ob) is associated with a reduced net free fatty acid (FFA) response to epinephrine compared with nonobese (Non Ob) and lower-body obese (LB Ob) women. Because catecholamines regulate some of the metabolic responses to exercise, we hypothesized that UB Ob would have a reduced net FFA response to exercise. Plasma FFA rate of appearance (Ra) ([1-14C]palnutate) and fatty acid oxidation (indirect calorimetry) were therefore measured during 2.5 h of stationary bicycle exercise (45% V̇O2 peak) in 13 UB Ob, 11 LB Ob, and 8 Non Ob premenopausal women. 10 UB Ob and 8 LB Ob women were retested after an ∼ 8-kg weight loss. Results: During exercise Non Ob and LB Ob women had greater increments in FFA availability (51±7 and 53±8 mmol, respectively) than UB Ob women (27±4 mmol, P < 0.05). Total exercise FFA availability and fatty acid oxidation were not different between Non Ob, LB Ob, and UB Ob women, however. Following weight loss (∼ 8 kg), the FFA response to exercise increased (P < 0.01) and remained greater (P < 0.05) in LB Ob than in UB Ob women. In conclusion, the FFA response to exercise was reduced in UB Ob women before and after weight loss, but no effects on fatty acid oxidation were apparent.
KW - Body composition
KW - Free fatty acids
KW - Indirect calorimetry
KW - Obesity
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=0027213748&partnerID=8YFLogxK
U2 - 10.1172/JCI116559
DO - 10.1172/JCI116559
M3 - Article
C2 - 8325992
AN - SCOPUS:0027213748
SN - 0021-9738
VL - 92
SP - 255
EP - 261
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 1
ER -