Fat/Dachsous family cadherins in cell and tissue organisation

Alexander D. Fulford, Helen McNeill

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume62
DOIs
StatePublished - Feb 2020

Keywords

  • Dachsous
  • Fat
  • Hippo signalling
  • Planar cell polarity

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