Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalCurrent Opinion in Cell Biology
StatePublished - Feb 2020


  • Dachsous
  • Fat
  • Hippo signalling
  • Planar cell polarity


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