TY - JOUR
T1 - Fat/Dachsous family cadherins in cell and tissue organisation
AU - Fulford, Alexander D.
AU - McNeill, Helen
N1 - Funding Information:
The authors thank the members of the McNeill lab for comments and stimulating discussing. Work in the McNeill lab is supported by grants from CIHR and start-up funds from Washington University School of Medicine in St. Louis .
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/2
Y1 - 2020/2
N2 - Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.
AB - Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.
KW - Dachsous
KW - Fat
KW - Hippo signalling
KW - Planar cell polarity
UR - http://www.scopus.com/inward/record.url?scp=85074893435&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2019.10.006
DO - 10.1016/j.ceb.2019.10.006
M3 - Review article
C2 - 31739265
AN - SCOPUS:85074893435
VL - 62
SP - 96
EP - 103
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -