Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation

William G. Woods; Louis P. Dehner; Mark E. Nesbit; William Krivit; Peter F. Coccia; Norma K.C. Ramsay; Tae H. Kim; John H. Kersey

doi:10.1016/0002-9343(80)90368-X

Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation

William G. Woods
, Louis P. Dehner
, Mark E. Nesbit
, William Krivit
, Peter F. Coccia
, Norma K.C. Ramsay
, Tae H. Kim
, John H. Kersey

Division of Anatomic and Molecular Pathology (AMP)

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.

Original language	English
Pages (from-to)	285-290
Number of pages	6
Journal	The American journal of medicine
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/0002-9343(80)90368-X
State	Published - Feb 1980

Access to Document

10.1016/0002-9343(80)90368-X

Cite this

@article{a76591f648d8453089dcf5f83f2398b0,

title = "Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation",

abstract = "In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.",

author = "Woods, \{William G.\} and Dehner, \{Louis P.\} and Nesbit, \{Mark E.\} and William Krivit and Coccia, \{Peter F.\} and Ramsay, \{Norma K.C.\} and Kim, \{Tae H.\} and Kersey, \{John H.\}",

note = "Funding Information: WILLIAM G. WOODS, M.D. LOUIS P. DEHNER, M.D. MARK E. NESBIT, M.D. WILLIAM KRIVIT, M.D., Ph.D. PETER F. COCCIA, M.D. NORMA K. C. RAMSAY, M.D. TAE H. KIM, M.D. JOHN H. KERSEY. M.D. Minneapolis. Minnesota From the Departments of Pediatrics, Laboratory Medicine and Pathology, and Radiation Therapy, University of Minnesota Hospitals, Minneapolis, Minnesota. This study was supported in part by Grants CA 21737, CA 18083, CA 15548 and CP 43384 from the National Cancer Institute. Requests for reprints should be addressed to Dr. William G. Woods, Department of Pediatrics-Hematology Division, Box 454 Mayo, University of Minnesota Hospitals. Minneapolis, Minnesota 55455. Manuscript accepted May 21.1979.",

year = "1980",

month = feb,

doi = "10.1016/0002-9343(80)90368-X",

language = "English",

volume = "68",

pages = "285--290",

journal = "The American journal of medicine",

issn = "0002-9343",

number = "2",

}

TY - JOUR

T1 - Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation

AU - Woods, William G.

AU - Dehner, Louis P.

AU - Nesbit, Mark E.

AU - Krivit, William

AU - Coccia, Peter F.

AU - Ramsay, Norma K.C.

AU - Kim, Tae H.

AU - Kersey, John H.

N1 - Funding Information: WILLIAM G. WOODS, M.D. LOUIS P. DEHNER, M.D. MARK E. NESBIT, M.D. WILLIAM KRIVIT, M.D., Ph.D. PETER F. COCCIA, M.D. NORMA K. C. RAMSAY, M.D. TAE H. KIM, M.D. JOHN H. KERSEY. M.D. Minneapolis. Minnesota From the Departments of Pediatrics, Laboratory Medicine and Pathology, and Radiation Therapy, University of Minnesota Hospitals, Minneapolis, Minnesota. This study was supported in part by Grants CA 21737, CA 18083, CA 15548 and CP 43384 from the National Cancer Institute. Requests for reprints should be addressed to Dr. William G. Woods, Department of Pediatrics-Hematology Division, Box 454 Mayo, University of Minnesota Hospitals. Minneapolis, Minnesota 55455. Manuscript accepted May 21.1979.

PY - 1980/2

Y1 - 1980/2

N2 - In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.

AB - In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.

UR - https://www.scopus.com/pages/publications/0018857771

U2 - 10.1016/0002-9343(80)90368-X

DO - 10.1016/0002-9343(80)90368-X

M3 - Article

C2 - 6986767

AN - SCOPUS:0018857771

SN - 0002-9343

VL - 68

SP - 285

EP - 290

JO - The American journal of medicine

JF - The American journal of medicine

IS - 2

ER -

Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this