TY - JOUR
T1 - Fatal COVID-19 infection in a patient with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
T2 - A case report
AU - Wongkittichote, Parith
AU - Watson, James R.
AU - Leonard, Jennifer M.
AU - Toolan, Elizabeth R.
AU - Dickson, Patricia I.
AU - Grange, Dorothy K.
N1 - Publisher Copyright:
© 2020 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Long-chain fatty-acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID-19) is a pandemic caused by the RNA virus SARS-CoV-2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID-19. She developed acute respiratory failure and refractory hypotension from severe cardiomyopathy which progressed to multiple organ failure and death. Our case illustrates the need for close monitoring of cardiac function in patients with a long-chain fatty acid oxidation disorder.
AB - Long-chain fatty-acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID-19) is a pandemic caused by the RNA virus SARS-CoV-2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID-19. She developed acute respiratory failure and refractory hypotension from severe cardiomyopathy which progressed to multiple organ failure and death. Our case illustrates the need for close monitoring of cardiac function in patients with a long-chain fatty acid oxidation disorder.
KW - COVID-19
KW - LCHAD
KW - cardiomyopathy
KW - fatty acid oxidation disorder
KW - long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
UR - http://www.scopus.com/inward/record.url?scp=85095952651&partnerID=8YFLogxK
U2 - 10.1002/jmd2.12165
DO - 10.1002/jmd2.12165
M3 - Article
C2 - 33204595
AN - SCOPUS:85095952651
SN - 2192-8304
VL - 56
SP - 40
EP - 45
JO - JIMD Reports
JF - JIMD Reports
IS - 1
ER -