FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.
- Van Maldergem syndrome
- kidney development