@article{18e33db1d340438fa6020431e4e58749,
title = "FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling",
abstract = "FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.",
keywords = "CAKUT, FAT4, RET, Van Maldergem syndrome, cadherin, kidney development, non-autonomous",
author = "Hongtao Zhang and Mazdak Bagherie-Lachidan and Caroline Badouel and Leonie Enderle and Philippos Peidis and Rod Bremner and Satu Kuure and Sanjay Jain and Helen McNeill",
note = "Funding Information: M.B.-L. was funded by OGS and CIHR awards. Grants to H.M. were provided by a CIHR Foundation award, the Terry Fox Research Institute , start-up funds from Washington University School of Medicine , and the BJC investigator program. S.J. is supported by R01 DK082531. Funding Information: We thank Dr. Mario Cappecchi for the Fat4EGFP/+ mouse line and Dr. Carl Bates for the Hoxb7-cre mice. We also thank Dr. Anne-Claude Gingras, Dr. Brian Raught, Dr. James Rini, Dr. Jane McGlade, and Dr. Jeffrey Milbrandt for plasmids. We are grateful to Dr. David Sprinzak for providing cell lines and Dr. Antoine Reginensi for assistance in in situ hybridization. We thank Bendi Gong for help in generating the RET signaling related plasmids. M.B.-L. was funded by OGS and CIHR awards. Grants to H.M. were provided by a CIHR Foundation award, the Terry Fox Research Institute, start-up funds from Washington University School of Medicine, and the BJC investigator program. S.J. is supported by R01 DK082531. H.Z. M.B.-L. and H.M. conceived the project. H.Z. and M.B.-L. designed and performed most of the experiments. L.E. generated the Tet-on-FAT4 stable cell line. C.B. and P.P. conducted some of the co-immunoprecipitation experiments. H.Z. M.B.-L. and H.M. analyzed the data and wrote the manuscript. P.P. R.B. S.K. and S.J. provided reagents and discussions and helped in writing the manuscript. H.M. supervised all aspects of the project. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = mar,
day = "25",
doi = "10.1016/j.devcel.2019.02.004",
language = "English",
volume = "48",
pages = "780--792.e4",
journal = "Developmental Cell",
issn = "1534-5807",
number = "6",
}