FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling

Hongtao Zhang; Mazdak Bagherie-Lachidan; Caroline Badouel; Leonie Enderle; Philippos Peidis; Rod Bremner; Satu Kuure; Sanjay Jain; Helen McNeill

doi:10.1016/j.devcel.2019.02.004

FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling

Hongtao Zhang, Mazdak Bagherie-Lachidan, Caroline Badouel, Leonie Enderle, Philippos Peidis, Rod Bremner, Satu Kuure, Sanjay Jain, Helen McNeill

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.

Original language	English
Pages (from-to)	780-792.e4
Journal	Developmental cell
Volume	48
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2019.02.004
State	Published - Mar 25 2019

Keywords

CAKUT
FAT4
RET
Van Maldergem syndrome
cadherin
kidney development
non-autonomous

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10.1016/j.devcel.2019.02.004

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title = "FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling",

abstract = "FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.",

keywords = "CAKUT, FAT4, RET, Van Maldergem syndrome, cadherin, kidney development, non-autonomous",

author = "Hongtao Zhang and Mazdak Bagherie-Lachidan and Caroline Badouel and Leonie Enderle and Philippos Peidis and Rod Bremner and Satu Kuure and Sanjay Jain and Helen McNeill",

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AU - Zhang, Hongtao

AU - Bagherie-Lachidan, Mazdak

AU - Badouel, Caroline

AU - Enderle, Leonie

AU - Peidis, Philippos

AU - Bremner, Rod

AU - Kuure, Satu

AU - Jain, Sanjay

AU - McNeill, Helen

PY - 2019/3/25

Y1 - 2019/3/25

N2 - FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.

AB - FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.

KW - CAKUT

KW - FAT4

KW - RET

KW - Van Maldergem syndrome

KW - cadherin

KW - kidney development

KW - non-autonomous

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DO - 10.1016/j.devcel.2019.02.004

M3 - Article

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VL - 48

SP - 780-792.e4

JO - Developmental cell

JF - Developmental cell

IS - 6

ER -

FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling

Abstract

Keywords

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