Fat stem cells

Jeffrey M. Gimble; Bruce A. Bunnell; Farshid Guilak

doi:10.1142/9781848161832_0008

Fat stem cells

Jeffrey M. Gimble, Bruce A. Bunnell, Farshid Guilak

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells. Adipose-derived stem cells (ASCs) can be isolated from human lipoaspirates by collagenase digestion, differential centrifugation, and plastic adherence. The ASCs display a consistent immunophenotype that is similar, but not identical, to that of bone marrow-derived mesenchymal stem cells (BMSCs). Like BMSCs, ASCs inhibit mixed lymphocyte reactions in vitro, suggesting that it will be possible to perform allogeneic transplants in clinical settings. The expanded ASCs are multipotent and can differentiate into adipocytes, chondrocytes, endothelial cells, myocytes, neuronal-like cells, and osteoblasts, among other lineages. Furthermore, genetic engineering methods can be applied to ASCs, allowing their potential use as gene delivery vehicles in vivo. This chapter reviews the expanding literature base relating to ASC applications for regenerative medicine.

Original language	English
Title of host publication	Advances in Tissue Engineering
Publisher	Imperial College Press
Pages	143-174
Number of pages	32
ISBN (Electronic)	9781848161832
ISBN (Print)	9781848161825
DOIs	https://doi.org/10.1142/9781848161832_0008
State	Published - Jan 1 2008

Keywords

Adipose-Derived Stem Cells (ASCs)
Cytokine Profile
Differentiation
Immunogenicity
Immunophenotype

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10.1142/9781848161832_0008

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Fat stem cells

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Keywords

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