Fat, salt and blood pressure: The leptin-renal axis

Cristian Del Carpio Tenorio; Pramesh Dhakal; Garry P. Reams; Ronald H. Freeman; Robert Spear; Kan Liu; Daniel Villarreal

Fat, salt and blood pressure: The leptin-renal axis

Cristian Del Carpio Tenorio, Pramesh Dhakal, Garry P. Reams, Ronald H. Freeman, Robert Spear, Kan Liu, Daniel Villarreal

Division of Cardiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake, elevation in temperature and energy expenditure. In addition, available evidence suggests that leptin, through both direct and indirect mechanisms, plays an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and for direct renal and vascular damage.

Original language	English
Title of host publication	Leptin
Subtitle of host publication	Biosynthesis, Functions and Clinical Significance
Publisher	Nova Science Publishers, Inc.
Pages	17-31
Number of pages	15
ISBN (Electronic)	9781629488059
ISBN (Print)	9781629488011
State	Published - Jan 1 2014

Cite this

@inbook{10211daeaea34c669aed271587569ede,

title = "Fat, salt and blood pressure: The leptin-renal axis",

abstract = "Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake, elevation in temperature and energy expenditure. In addition, available evidence suggests that leptin, through both direct and indirect mechanisms, plays an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and for direct renal and vascular damage.",

author = "{Del Carpio Tenorio}, Cristian and Pramesh Dhakal and Reams, {Garry P.} and Freeman, {Ronald H.} and Robert Spear and Kan Liu and Daniel Villarreal",

year = "2014",

month = jan,

day = "1",

language = "English",

isbn = "9781629488011",

pages = "17--31",

booktitle = "Leptin",

publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Fat, salt and blood pressure

T2 - The leptin-renal axis

AU - Del Carpio Tenorio, Cristian

AU - Dhakal, Pramesh

AU - Reams, Garry P.

AU - Freeman, Ronald H.

AU - Spear, Robert

AU - Liu, Kan

AU - Villarreal, Daniel

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake, elevation in temperature and energy expenditure. In addition, available evidence suggests that leptin, through both direct and indirect mechanisms, plays an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and for direct renal and vascular damage.

AB - Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake, elevation in temperature and energy expenditure. In addition, available evidence suggests that leptin, through both direct and indirect mechanisms, plays an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and for direct renal and vascular damage.

UR - http://www.scopus.com/inward/record.url?scp=84951170717&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84951170717

SN - 9781629488011

SP - 17

EP - 31

BT - Leptin

PB - Nova Science Publishers, Inc.

ER -

Fat, salt and blood pressure: The leptin-renal axis

Abstract

Other files and links

Fingerprint

Cite this