Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterolabsorption and LDL cholesterol

Curtis A. Spilburg, Anne C. Goldberg, Janet B. McGill, William F. Stenson, Susan B. Racette, Joyce Bateman, Timothy B. McPherson, Richard E. Ostlund

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Objective The objective of this work was to show that fat-free, lecithin-formulated soy stanols lower cholesterol absorption and serum LDL cholesterol. Design Reduction in cholesterol absorption was measured in paired single-meal tests with or without formulated soy stanols (acute test), and changes in serum lipids were investigated in a 10-week, randomized, double-blind parallel trial in which formulated stanols or lecithin vehicle were given three times daily for the last 4 weeks (chronic test). Subjects/setting Forty-five normal or mildly hypercholesterolemic subjects were recruited for both studies. The 21 subjects (16 female, 5 male; mean age 32.5 years) in the absorption studies had the following mean lipid values: LDL cholesterol, 2.79 mmol/L and total cholesterol, 4.73 mmol/L. For the lipid reduction, 24 subjects (16 female, 8 male; mean age 50.6 years) were enrolled with mean LDL cholesterol and total cholesterol of 3.72 mmol/L and 5.66 mmol/L, respectively. Intervention Reduction in cholesterol absorption was measured using a lemonade beverage or egg whites that contained 625 mg stanols. Throughout the chronic study, subjects followed the American Heart Association Step I diet. During the 4-week treatment phase, subjects consumed daily a lemonade-flavored beverage containing either placebo or formulated soy stanols (1.9 g). Main outcome measures Inhibition of cholesterol absorption was determined from the difference in plasma deuterated cholesterol enrichment after a test meal containing stanol-lecithin and one with lecithin vehicle only. In the chronic study, the primary endpoints were changes in LDL and total cholesterol. Statistical analyses performed Paired or unpaired t tests were used to determine statistical significance. Results Stanol-lecithin reduced cholesterol absorption by 32.1% (P=.0045, n=10) and by 38.2% (P=.0022, n=11) when delivered in a lemonade-flavored beverage and in egg whites, respectively. Reduction in cholesterol absorption was strongly related to the initial level of absorbed cholesterol tracer in serum (rs=-0.739). Stanol-lecithin given in a beverage reduced total serum cholesterol by 10.1% (P=.0019, n=24) and LDL cholesterol by 14.3% (P=.0016, n=24). Applications/conclusions Powdered soy stanol-lecithin lowers cholesterol absorption and LDL cholesterol when consumed in fat-free foods. J Am Diet Assoc. 2003;103:577-581.

Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalJournal of the American Dietetic Association
Issue number5
StatePublished - May 2003


Dive into the research topics of 'Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterolabsorption and LDL cholesterol'. Together they form a unique fingerprint.

Cite this