Cell growth and patterning are critical for tissue development. Here we discuss the evolutionarily conserved cadherins, Fat and Dachsous, and the roles they play during mammalian tissue development and disease. In Drosophila, Fat and Dachsous regulate tissue growth via the Hippo pathway and planar cell polarity (PCP). The Drosophila wing has been an ideal tissue to observe how mutations in these cadherins affect tissue development. In mammals, there are multiple Fat and Dachsous cadherins, which are expressed in many tissues, but mutations in these cadherins that affect growth and tissue organization are context dependent. Here we examine how mutations in the Fat and Dachsous mammalian genes affect development in mammals and contribute to human disease.

Original languageEnglish
Title of host publicationCell Polarity in Development and Disease
PublisherAcademic Press Inc.
Number of pages22
ISBN (Print)9780128201589
StatePublished - Jan 2023

Publication series

NameCurrent Topics in Developmental Biology
ISSN (Print)0070-2153


  • Cadherins
  • Dachsous cadherins
  • Dchs1
  • Dchs2
  • Development
  • Fat cadherins
  • Fat1
  • Fat2
  • Fat3
  • Fat4
  • Hippo pathway
  • Mice
  • Patterning
  • Proliferation


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