TY - JOUR
T1 - Fast mapping of myocardial blood flow with MR first-pass perfusion imaging
AU - Goldstein, Thomas A.
AU - Jerosch-Herold, Michael
AU - Misselwitz, Bernd
AU - Zhang, Haosen
AU - Gropler, Robert J.
AU - Zheng, Jie
PY - 2008/6
Y1 - 2008/6
N2 - Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the calculation of MBF with few assumptions on the shapes of residue curves. Simulation was performed to evaluate the accuracy of this algorithm in the determination of MBF. To examine our algorithm in vivo, studies were performed in nine normal dogs. Two first-pass perfusion imaging sessions were performed with the administration of the intravascular contrast agent Gadomer at rest and during dipyridamole-induced vasodilation. Radiolabeled microspheres were injected to measure MBF at the same time. MBF measurements in dogs using MR methods correlated well with the microsphere measurements (R 2 = 0.96, slope = 0.9), demonstrating a fair accuracy in the perfusion measurements at rest and during the vasodilation stress. In addition to its accuracy, this method can also be optimized to run relatively fast, providing potential for fast and accurate myocardial perfusion mapping in a clinical setting.
AB - Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-by-pixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the calculation of MBF with few assumptions on the shapes of residue curves. Simulation was performed to evaluate the accuracy of this algorithm in the determination of MBF. To examine our algorithm in vivo, studies were performed in nine normal dogs. Two first-pass perfusion imaging sessions were performed with the administration of the intravascular contrast agent Gadomer at rest and during dipyridamole-induced vasodilation. Radiolabeled microspheres were injected to measure MBF at the same time. MBF measurements in dogs using MR methods correlated well with the microsphere measurements (R 2 = 0.96, slope = 0.9), demonstrating a fair accuracy in the perfusion measurements at rest and during the vasodilation stress. In addition to its accuracy, this method can also be optimized to run relatively fast, providing potential for fast and accurate myocardial perfusion mapping in a clinical setting.
KW - Blood flow
KW - Central volume principle
KW - Intravascular contrast agent
KW - MR
KW - Myocardial perfusion
KW - Vasodilation
UR - http://www.scopus.com/inward/record.url?scp=44949219340&partnerID=8YFLogxK
U2 - 10.1002/mrm.21559
DO - 10.1002/mrm.21559
M3 - Article
C2 - 18421680
AN - SCOPUS:44949219340
SN - 0740-3194
VL - 59
SP - 1394
EP - 1400
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 6
ER -