Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

R. E. Schmidt, F. M. Matschinsky, D. A. Godfrey, A. D. Williams, D. B. McDougal

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20 per cent and ChAc accumulation by about 40 per cent. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.

Original languageEnglish
Pages (from-to)1081-1085
Number of pages5
JournalUnknown Journal
Issue number12
StatePublished - Jan 1 1975


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