Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

R. E. Schmidt; F. M. Matschinsky; D. A. Godfrey; A. D. Williams; D. B. McDougal

doi:10.2337/diab.24.12.1081

Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

R. E. Schmidt, F. M. Matschinsky, D. A. Godfrey, A. D. Williams, D. B. McDougal

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Abstract

Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20 per cent and ChAc accumulation by about 40 per cent. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.

Original language	English
Pages (from-to)	1081-1085
Number of pages	5
Journal	Unknown Journal
Volume	24
Issue number	12
DOIs	https://doi.org/10.2337/diab.24.12.1081
State	Published - Jan 1 1975

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10.2337/diab.24.12.1081

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abstract = "Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20 per cent and ChAc accumulation by about 40 per cent. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.",

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AU - Matschinsky, F. M.

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AU - Williams, A. D.

AU - McDougal, D. B.

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Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

Abstract

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