FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits

Megan Bowers, Tong Liang, Daniel Gonzalez-Bohorquez, Sara Zocher, Baptiste N. Jaeger, Werner J. Kovacs, Clemens Röhrl, Kaitlyn M.L. Cramb, Jochen Winterer, Merit Kruse, Slavica Dimitrieva, Rupert W. Overall, Thomas Wegleiter, Hossein Najmabadi, Clay F. Semenkovich, Gerd Kempermann, Csaba Földy, Sebastian Jessberger

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Using mouse and human tissue genome engineering, Bowers et al. show that a human variant in fatty acid synthase (FASN) provides a link between altered lipid metabolism, neurogenic stem/progenitor activity, and brain function.

Original languageEnglish
Pages (from-to)98-109.e11
JournalCell Stem Cell
Volume27
Issue number1
DOIs
StatePublished - Jul 2 2020

Keywords

  • cognition
  • disease modeling
  • genome editing
  • hippocampus
  • intellectual disability
  • learning
  • lipid metabolism
  • neural stem cell
  • neurogenesis
  • organoid

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