TY - JOUR
T1 - Fas stimulation results in selective islet infiltrate apoptosis in Situ and reversal of diabetes
AU - Dharnidharka, Vikas R.
AU - Van Patten, Yancy
AU - Rena Bahjat, F.
AU - Clare-Salzler, Michael
PY - 2002
Y1 - 2002
N2 - Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.
AB - Breakdown of peripheral T cell regulation due to defective antigen-activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet-infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.
KW - Activation-induced cell death
KW - T cell apoptosis
KW - Type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0036271458&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2002.tb02960.x
DO - 10.1111/j.1749-6632.2002.tb02960.x
M3 - Article
C2 - 12021097
AN - SCOPUS:0036271458
SN - 0077-8923
VL - 958
SP - 160
EP - 162
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -