Family-based genome-wide association scan of attention-deficit/ hyperactivity disorder

Eric Mick, Alexandre Todorov, Susan Smalley, Xiaolan Hu, Sandra Loo, Richard D. Todd, Joseph Biederman, Deirdre Byrne, Bryan Dechairo, Allan Guiney, James McCracken, James McGough, Stanley F. Nelson, Angela M. Reiersen, Timothy E. Wilens, Janet Wozniak, Benjamin M. Neale, Stephen V. Faraone

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Objective: Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD. Method: Families were ascertained at Massachusetts General Hospital (MGH; N = 309 trios), Washington University at St. Louis (WASH-U; N = 272 trios), and University of California at Los Angeles (UCLA; N = 156 trios). Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. After applying quality control filters, association with ADHD was tested with 835,136 SNPs in 735 DSM-IV ADHD trios from 732 families. Results: Our smallest p value (6.7E-07) did not reach the threshold for genome-wide statistical significance (5.0E-08), but one of the 20 most significant associations was located in a candidate gene of interest for ADHD (SLC9A9, rs9810857, p = 6.4E-6). We also conducted gene-based tests of candidate genes identified in the literature and found additional evidence of association with SLC9A9. Conclusions: We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders.

Original languageEnglish
Pages (from-to)898-905.e3
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume49
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • ADHD
  • SLC9A9
  • genome-wide association study

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