Familiality of triglyceride and LPL response to exercise training: The heritage study

Y. Hong, T. Rice, J. Gagnon, L. Perusse, M. Province, C. Bouchard, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, J. P. Despres

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Purpose: The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (ΔPH-LPL) activity and triglyceride (ΔTG) levels in response to exercise training. Additional hypotheses were also tested as to whether there were familial/genetic factors shared by baseline and the corresponding response to exercise training (i.e., by baseline triglyceride (TG(B)) and ΔTG and by baseline postheparin lipoprotein lipase (PH-LPL(B)) and ΔPH-LPL activity). Methods: Serum TG and PH-LPL were measured in 459 subjects from 99 sedentary Caucasian families of the HERITAGE Family study before (baseline) and after completing a 20 wk (3 times per week) exercise training protocol. The training protocol had a target intensity of 75% of the heart rate associated with baseline VO(2max) during the last 6 wk. PH-LPL activity was measured in the study subjects. Both univariate and bivariate familial correlation analyses were applied to the baseline and response data. Results: The maximal heritabilities for ΔTG and ΔPH-LPL activity were 22% and 15%, respectively. There were no common familial factors for TG(B) and ΔTG, nor were there any for PH-LPL(B) and ΔPH-LPL. However, we found that there were common familial factors underlying ΔTG and ΔPH-LPL; these familial factors seemed to differ across sex and generation groups. Conclusion: Although there were no common familial factors underlying the covariation between the baseline triglyceride and PH-LPL activity and the corresponding responses to exercise training (i.e., TG(B) with ΔTG or PH-LPL(B) with ΔPH-LPL), the ΔTG and ΔPH-LPL covariation apparently share some common familial determinants.

Original languageEnglish
Pages (from-to)1438-1444
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume32
Issue number8
DOIs
StatePublished - Jan 1 2000

Keywords

  • Familial correlation
  • Genetic epidemiology
  • Heritability
  • Pleiotropy

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