Familial transmission of a serious disease-producing group a streptococcus clone: Case reports and review

M. A. Gamba, M. Martinelli, H. J. Schaad, R. A. Streuli, J. Dipersio, L. Matter, H. B. Ris, F. Marchal, E. L. Kaplan, D. L. Stevens, R. Malinverni

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Abstract

Invasive group A streptococcus (GAS) infections are emerging diseases; however, person-to-person transmission of invasive GAS producing life- threatening infection has been observed rarely. We report a small intrafamilial cluster of life-threatening GAS infections. A previously healthy 47-year-old father developed necrotizing fasciitis of the neck. Two days later, his 16-year-old daughter developed streptococcal angina, pneumonia, and pleural empyema. Both patients had signs of streptococcal toxic shock syndrome. Pulsed field gel electrophoresis revealed that the M6 strains of GAS isolated from the father and daughter had identical patterns. Cases of person-to-person transmission of invasive GAS infection reported in the literature are also reviewed.

Original languageEnglish
Pages (from-to)1118-1121
Number of pages4
JournalClinical Infectious Diseases
Volume24
Issue number6
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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    Gamba, M. A., Martinelli, M., Schaad, H. J., Streuli, R. A., Dipersio, J., Matter, L., Ris, H. B., Marchal, F., Kaplan, E. L., Stevens, D. L., & Malinverni, R. (1997). Familial transmission of a serious disease-producing group a streptococcus clone: Case reports and review. Clinical Infectious Diseases, 24(6), 1118-1121. https://doi.org/10.1086/513636