Familial resemblance for abdominal visceral fat: The HERITAGE family study

T. Rice, J. P. Després, E. W. Daw, J. Gagnon, I. B. Borecki, L. Pérusse, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, C. Bouchard

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

OBJECTIVES: Abdominal visceral fat (AVF) is considered a risk factor for diabetes, atherogenic lipid profiles and hypertension. However, little is known about the genetic contribution to AVF as compared to total body fat. DESIGN: AVF was assessed by computerized tomography, and total body fat (fat mass) was assessed by underwater weighing in 86 families participating in the Heritage Family Study. All family members were sedentary at baseline examination. The familial factors underlying the variability in age-adjusted AVF, age-fat mass-adjusted AVF and age-adjusted fat mass, were assessed using a familial correlation model. RESULTS: The maximal heritability (including genetic and familial environmental effects) for AVF was comparable before (47%) and after (48%) adjusting for fat mass, and was 55% for fat mass itself in these sedentary families. Spouse correlations were significant for fat mass and for AVF prior to, but not after, adjustment for fat mass. CONCLUSIONS: These results confirm the only previous study which investigated the familial aggregation of AVF (both in pattern and magnitude), suggesting that the factors underlying AVF in these sedentary families may be similar to those in the population at large. Although both genetic and familial environmental factors probably influence each of fat mass and AVF, there appears to be a predominantly genetic etiology for the visceral component which is independent of total body fat. These findings imply that some individuals are more at risk than others because of an inherited tendency to store abdominal fat viscerally rather than subcutaneously.

Original languageEnglish
Pages (from-to)1024-1031
Number of pages8
JournalInternational Journal of Obesity
Volume21
Issue number11
DOIs
StatePublished - 1997

Keywords

  • Heritability
  • Sedentary
  • Total fat mass

Fingerprint

Dive into the research topics of 'Familial resemblance for abdominal visceral fat: The HERITAGE family study'. Together they form a unique fingerprint.

Cite this