Familial Hypercholesterolemia

Victoria Enchia Bouhairie; Anne Carol Goldberg

doi:10.1016/j.ecl.2015.09.001

Familial Hypercholesterolemia

Victoria Enchia Bouhairie
, Anne Carol Goldberg

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.

Original language	English
Pages (from-to)	1-16
Number of pages	16
Journal	Endocrinology and Metabolism Clinics of North America
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2015.09.001
State	Published - Mar 1 2016

Keywords

Bile acid sequestrants
Ezetimibe
Familial hypercholesterolemia
LDL apheresis
Lomitapide
Mipomersen
Statins

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10.1016/j.ecl.2015.09.001

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title = "Familial Hypercholesterolemia",

abstract = "Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.",

keywords = "Bile acid sequestrants, Ezetimibe, Familial hypercholesterolemia, LDL apheresis, Lomitapide, Mipomersen, Statins",

author = "Bouhairie, \{Victoria Enchia\} and Goldberg, \{Anne Carol\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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doi = "10.1016/j.ecl.2015.09.001",

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T1 - Familial Hypercholesterolemia

AU - Bouhairie, Victoria Enchia

AU - Goldberg, Anne Carol

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.

AB - Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.

KW - Bile acid sequestrants

KW - Ezetimibe

KW - Familial hypercholesterolemia

KW - LDL apheresis

KW - Lomitapide

KW - Mipomersen

KW - Statins

UR - https://www.scopus.com/pages/publications/84958167907

U2 - 10.1016/j.ecl.2015.09.001

DO - 10.1016/j.ecl.2015.09.001

M3 - Review article

C2 - 26892994

AN - SCOPUS:84958167907

SN - 0889-8529

VL - 45

SP - 1

EP - 16

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 1

ER -

Familial Hypercholesterolemia

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Keywords

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