TY - JOUR
T1 - Familial hypercholesterolemia
AU - Bouhairie, Victoria Enchia
AU - Goldberg, Anne Carol
N1 - Funding Information:
Conflict of Interest Statement: Dr V.E. Bouhairie receives support from Award Number T32DK007120 from the National Institute of Diabetes and Digestive and Kidney Diseases . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health; Dr A.C. Goldberg: Research Support: Research contracts to institution— Merck , Genzyme/ISIS/Sanofi-Aventis , GlaxoSmithKline , Amgen , Amarin , Regeneron/Sanofi-Aventis , Roche/Genentech , Pfizer ; Consulting: Tekmira, Astra-Zeneca, uniQure; Editorial: Merck Manual.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.
AB - Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.
KW - Bile acid sequestrants
KW - Ezetimibe
KW - Familial hypercholesterolemia
KW - LDL apheresis
KW - Lomitapide
KW - Mipomersen
KW - Statins
UR - http://www.scopus.com/inward/record.url?scp=84928792162&partnerID=8YFLogxK
U2 - 10.1016/j.ccl.2015.01.001
DO - 10.1016/j.ccl.2015.01.001
M3 - Review article
C2 - 25375248
AN - SCOPUS:84928792162
SN - 0733-8651
VL - 33
SP - 169
EP - 179
JO - Cardiology Clinics
JF - Cardiology Clinics
IS - 2
ER -