TY - JOUR
T1 - Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis
AU - Greenberg, Benjamin M.
AU - Casper, Theron Charles
AU - Mar, Soe S.
AU - Ness, Jayne M.
AU - Plumb, Patricia
AU - Liang, Shannon
AU - Goyal, Manu
AU - Weinstock-Guttman, Bianca
AU - Rodriguez, Moses
AU - Aaen, Gregory S.
AU - Belman, Anita
AU - Barcellos, Lisa F.
AU - Rose, John W.
AU - Gorman, Mark P.
AU - Benson, Leslie A.
AU - Candee, Meghan
AU - Chitnis, Tanuja
AU - Harris, Yolanda C.
AU - Kahn, Ilana L.
AU - Roalstad, Shelly
AU - Hart, Janace
AU - Lotze, Timothy E.
AU - Rensel, Mary
AU - Rubin, Jennifer P.
AU - Schreiner, Teri L.
AU - Tillema, Jan Mendelt
AU - Waldman, Amy Tara
AU - Krupp, Lauren
AU - Graves, Jennifer
AU - Drake, Kaylea
AU - Waubant, Emmanuelle
N1 - Publisher Copyright:
Copyright © 2021 The Author(s).
PY - 2021/9/5
Y1 - 2021/9/5
N2 - Background and Objective: The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods: Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results: There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion: The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.
AB - Background and Objective: The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods: Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results: There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion: The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.
UR - http://www.scopus.com/inward/record.url?scp=85113657515&partnerID=8YFLogxK
U2 - 10.1212/NXI.0000000000001049
DO - 10.1212/NXI.0000000000001049
M3 - Article
C2 - 34353894
AN - SCOPUS:85113657515
SN - 2332-7812
VL - 8
JO - Neurology: Neuroimmunology and NeuroInflammation
JF - Neurology: Neuroimmunology and NeuroInflammation
IS - 5
M1 - e1049
ER -