Familial correlates of risk: Application to the gershon and goldin NIMH pedigree data

Sheila B. Gilligan, John P. Rice

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Survival analysis of familial covariates of risk for affective illness demonstrated a significant effect on the proband's diagnosis when affection status included bipolar illness, but not major depressive disorder. A cohort effect was indicated only when broad spectra (including bipolar II and major depressive disorder) of illness were defined. Multifactorial analyses of familial correlations for affective illness evidenced neither sex‐specific correlations nor prevalences. We suggest the examination of risk variables prior to undertaking familial analysis.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalGenetic Epidemiology
Volume6
Issue number1
DOIs
StatePublished - 1989

Keywords

  • affective disorder
  • bipolar illness
  • cohort effect
  • multifactorial analysis
  • survival analysis

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