Keyphrases
Presenilin
100%
Clinical Phenotype
100%
Disease-causing mutations
100%
Familial Alzheimer's Disease
100%
Calcium Homeostasis
100%
Endoplasmic Reticulum Calcium
100%
Endoplasmic Reticulum Ca2+
66%
Ca2+ Leak
44%
Ca2+
33%
Lymphoblast
33%
Alzheimer's Disease Patient
22%
Monogenic
11%
Endoplasmic Reticulum
11%
Presenilin 2
11%
Human Disease
11%
Functional mutation
11%
Exon 8
11%
Catalytic Subunit
11%
Early Alzheimer's Disease
11%
Mouse Embryonic Fibroblasts
11%
Secretase
11%
Double Knockout Mice
11%
Rescue Experiments
11%
Ca2+ Imaging
11%
Leakage Channel
11%
Secretase Activity
11%
Spastic Paraparesis
11%
Amyloid Protein Precursor
11%
Familial AD
11%
PSEN1 Gene
11%
Sporadic AD
11%
Cotton Wool Plaques
11%
Biochemistry, Genetics and Molecular Biology
Presenilin
100%
Calcium Homeostasis
100%
Lymphoblast
42%
Secretase
28%
Enzyme Active Site
14%
Knockout Mouse
14%
Amyloid Precursor Protein
14%
Exon
14%
PSEN1
14%
Fibroblast
14%