@article{8f314965ed674e43aaaa1f1499134676,
title = "Failure of acetazolamide to decrease intraocular pressure in patients with carbonic anhydrase II deficiency",
abstract = "The effect of the carbonic anhydrase inhibitor acetazolamide on intraocular pressure was studied in two patients with carbonic anhydrase II deficiency and in six control subjects. The deficient patients had the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. A dose of 125 mg of intravenous acetazolamide caused a significant (P<.01) decrease in intraocular pressure from baseline (15.0 ± 1.5 mm Hg) in the control subjects one hour (11.3 ± 1.5 mm Hg) and four hours (13.8 ± 1.2 mm Hg) after drug administration. In contrast, the patients with carbonic anhydrase deficiency showed no such decrease in intraocular pressure; baseline intraocular pressure (19.2 ± 0.2 mm Hg) was significantly unchanged (P>.5) at one hour (20.0 ± 0.1 mm Hg) and four hours (19.2 ± 0.2 mm Hg).",
author = "Theodore Krupin and Sly, {William S.} and Whyte, {Michael P.} and Dodgson, {Susanna J.}",
note = "Funding Information: From the Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Dr. Krupin); the Division of Medical Genetics, Departments of Medicine and Genetics (Dr. Sly) and the Division of Bone and Mineral Metabolism, Departments of Medicine and Pediatrics (Dr. Whyte), Washington University School of Medicine, St. Louis, Missouri; and the Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Dr. Dodgson). This study was supported in part by grants EY05267, RR-00036, GM 31988, and AIIGM 20610 from the National Institutes of Health, Bethesda, the National Foundation-March of Dimes (Washington University), and the F. Roland and Marianne E. Sargent Teaching and Research Fund (University of Pennsylvania).",
year = "1985",
month = apr,
day = "15",
doi = "10.1016/0002-9394(85)90004-2",
language = "English",
volume = "99",
pages = "396--399",
journal = "American journal of ophthalmology",
issn = "0002-9394",
number = "4",
}