TY - JOUR
T1 - Factors Which Regulate Net Hepatic Glucose Uptake In Vivo
AU - Cherrington, Alan D.
AU - Pagliassotti, Michael J.
AU - Myers, Sharon R.
AU - Adkins-Marshall, Bess
AU - Mcguinness, Owen P.
PY - 1991/5
Y1 - 1991/5
N2 - The regulation of net hepatic glucose uptake in vivo occurs by way of the hormonal milieu (insulin and glucagon), the glucose level, and the route of glucose delivery. Hyperglycemia in the absence of changes in pancreatic hormones (i.e., increased insulin and/or decreased glucagon) does not elicit significant glucose uptake by the liver. Net hepatic glucose uptake is augmented in a dose-dependent manner by a rise in insulin and is further stimulated by the presence of a “portal signal.” The presence of coordinated changes in insulin, glucagon, and the glucose level in combination with the “portal signal” ensures adequate glucose uptake by the liver in response to a meal.
AB - The regulation of net hepatic glucose uptake in vivo occurs by way of the hormonal milieu (insulin and glucagon), the glucose level, and the route of glucose delivery. Hyperglycemia in the absence of changes in pancreatic hormones (i.e., increased insulin and/or decreased glucagon) does not elicit significant glucose uptake by the liver. Net hepatic glucose uptake is augmented in a dose-dependent manner by a rise in insulin and is further stimulated by the presence of a “portal signal.” The presence of coordinated changes in insulin, glucagon, and the glucose level in combination with the “portal signal” ensures adequate glucose uptake by the liver in response to a meal.
UR - http://www.scopus.com/inward/record.url?scp=0026055170&partnerID=8YFLogxK
U2 - 10.1177/014860719101500371S
DO - 10.1177/014860719101500371S
M3 - Article
C2 - 1865561
AN - SCOPUS:0026055170
SN - 0148-6071
VL - 15
SP - 71S-73S
JO - Journal of Parenteral and Enteral Nutrition
JF - Journal of Parenteral and Enteral Nutrition
IS - 3
ER -