Factors Which Regulate Net Hepatic Glucose Uptake In Vivo

Alan D. Cherrington, Michael J. Pagliassotti, Sharon R. Myers, Bess Adkins-Marshall, Owen P. Mcguinness

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The regulation of net hepatic glucose uptake in vivo occurs by way of the hormonal milieu (insulin and glucagon), the glucose level, and the route of glucose delivery. Hyperglycemia in the absence of changes in pancreatic hormones (i.e., increased insulin and/or decreased glucagon) does not elicit significant glucose uptake by the liver. Net hepatic glucose uptake is augmented in a dose-dependent manner by a rise in insulin and is further stimulated by the presence of a “portal signal.” The presence of coordinated changes in insulin, glucagon, and the glucose level in combination with the “portal signal” ensures adequate glucose uptake by the liver in response to a meal.

Original languageEnglish
Pages (from-to)71S-73S
JournalJournal of Parenteral and Enteral Nutrition
Volume15
Issue number3
DOIs
StatePublished - May 1991

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