TY - JOUR
T1 - Factors related to outcome of salvage therapy for isolated cervical recurrence of squamous cell carcinoma in the previously treated neck
T2 - A multi-institutional study
AU - Krol, Bryan J.
AU - Righi, Paul D.
AU - Paydarfar, Joseph A.
AU - Cheng, Elbert T.
AU - Smith, Ronald M.
AU - Lai, Daniel C.
AU - Bhargava, Vaibhav
AU - Piccirillo, Jay F.
AU - Hayes, John T.
AU - Lue, Allen J.
AU - Scher, Richard L.
AU - Weisberger, Edward C.
AU - Wilson, Keith M.
AU - Tran, Lynn E.
AU - Rizk, Nabil
AU - Pellitteri, Phillip K.
AU - Terris, David J.
N1 - Funding Information:
Funding for statistical analysis was provided by the Indiana University Department of Otolaryngology—Head and Neck Surgery.
PY - 2000
Y1 - 2000
N2 - OBJECTIVE: The goal was to identify factors associated with the outcome of salvage therapy for patients with isolated cervical recurrences of squamous cell carcinoma in the previously treated neck (ICR-PTN). STUDY DESIGN AND SETTINGS: A tumor registry search for ICR-PTN patients was performed at 7 participating institutions, and the charts were reviewed. Kaplan-Meier plots for survival and time until re-recurrence were used to evaluate the significance of associated variables. RESULTS: Median survival and time until re-recurrence were both 11 months. Survival was better in patients with the following characteristics: nonsurgical initial neck treatment, negative initial disease resection margins, no history of prior recurrence, ipsilateral location of the ICR-PTN relative to the primary, and use of surgical salvage. CONCLUSIONS: By pooling the experience of 7 US tertiary care medical centers, we have identified 5 factors that are associated with outcome of salvage therapy for ICR-PTN. SIGNIFICANCE: Consideration of these factors, as well as the reviewed literature, should facilitate patient selection for salvage protocols.
AB - OBJECTIVE: The goal was to identify factors associated with the outcome of salvage therapy for patients with isolated cervical recurrences of squamous cell carcinoma in the previously treated neck (ICR-PTN). STUDY DESIGN AND SETTINGS: A tumor registry search for ICR-PTN patients was performed at 7 participating institutions, and the charts were reviewed. Kaplan-Meier plots for survival and time until re-recurrence were used to evaluate the significance of associated variables. RESULTS: Median survival and time until re-recurrence were both 11 months. Survival was better in patients with the following characteristics: nonsurgical initial neck treatment, negative initial disease resection margins, no history of prior recurrence, ipsilateral location of the ICR-PTN relative to the primary, and use of surgical salvage. CONCLUSIONS: By pooling the experience of 7 US tertiary care medical centers, we have identified 5 factors that are associated with outcome of salvage therapy for ICR-PTN. SIGNIFICANCE: Consideration of these factors, as well as the reviewed literature, should facilitate patient selection for salvage protocols.
UR - https://www.scopus.com/pages/publications/0033772140
U2 - 10.1067/mhn.2000.107680
DO - 10.1067/mhn.2000.107680
M3 - Article
C2 - 11020170
AN - SCOPUS:0033772140
SN - 0194-5998
VL - 123
SP - 368
EP - 376
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 4
ER -