Prior electrical activity in the indirect flight muscles of Drosphila facilitates membrane excitability. The mechanism of facilitation involves the inactivation of an early, fast, transient outward current by prior membrane depolarization. In the facilitated state the calcium-dependent spike-like response has a decreased current and voltage threshold. The facilitated state persists for 1.5 sec after a membrane active response. A single nerve-driven spike is sufficient to facilitate membrane excitability.

Original languageEnglish
Pages (from-to)6216-6220
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number10 II
StatePublished - 1980


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