Facilitation of lordosis behavior by clonidine in female guinea pigs

William R. Crowley; Bruce L. Nock; Harvey H. Feder

doi:10.1016/0091-3057(78)90339-8

Facilitation of lordosis behavior by clonidine in female guinea pigs

William R. Crowley, Bruce L. Nock, Harvey H. Feder

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Lordosis behavior was induced in previously unreceptive, ovariectomized estrogen-primed female guinea pigs by administration of the noradrenergic agonist clonidine. Clonidine also enhanced lordosis responding in females that were weakly receptive after estrogen priming. Unlike progesterone, the lordosis-facilitating effect of clonidine was not accompanied by a subsequent refractory period. Clonidine had a weak lordosis facilitatory effect when administered during the decline in receptivity to estrogen plus progesterone-primed animals and failed to induce lordosis when administered during the refractory period.

Original language	English
Pages (from-to)	207-209
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(78)90339-8
State	Published - Feb 1978

Keywords

Clonidine
Estrogen
Lordosis
Progesterone

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10.1016/0091-3057(78)90339-8

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title = "Facilitation of lordosis behavior by clonidine in female guinea pigs",

abstract = "Lordosis behavior was induced in previously unreceptive, ovariectomized estrogen-primed female guinea pigs by administration of the noradrenergic agonist clonidine. Clonidine also enhanced lordosis responding in females that were weakly receptive after estrogen priming. Unlike progesterone, the lordosis-facilitating effect of clonidine was not accompanied by a subsequent refractory period. Clonidine had a weak lordosis facilitatory effect when administered during the decline in receptivity to estrogen plus progesterone-primed animals and failed to induce lordosis when administered during the refractory period.",

keywords = "Clonidine, Estrogen, Lordosis, Progesterone",

author = "Crowley, {William R.} and Nock, {Bruce L.} and Feder, {Harvey H.}",

note = "Funding Information: Contribution No. 260 from the Institute of Animal Behavior. This research was supported by Research Grant HD-IM467 from NIH and by Research Scientist Development Award MH-29006 (H.H.F.) and by Training Grant GM-1125 OV.R.C. and B.L.N.). We thank Boehringer lngelheim Ltd. (clonidine) and Schering Corporation (EB, progesterone) for their generous gifts of the drugs used.",

year = "1978",

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doi = "10.1016/0091-3057(78)90339-8",

language = "English",

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journal = "Pharmacology, Biochemistry and Behavior",

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T1 - Facilitation of lordosis behavior by clonidine in female guinea pigs

AU - Crowley, William R.

AU - Nock, Bruce L.

AU - Feder, Harvey H.

N1 - Funding Information: Contribution No. 260 from the Institute of Animal Behavior. This research was supported by Research Grant HD-IM467 from NIH and by Research Scientist Development Award MH-29006 (H.H.F.) and by Training Grant GM-1125 OV.R.C. and B.L.N.). We thank Boehringer lngelheim Ltd. (clonidine) and Schering Corporation (EB, progesterone) for their generous gifts of the drugs used.

PY - 1978/2

Y1 - 1978/2

N2 - Lordosis behavior was induced in previously unreceptive, ovariectomized estrogen-primed female guinea pigs by administration of the noradrenergic agonist clonidine. Clonidine also enhanced lordosis responding in females that were weakly receptive after estrogen priming. Unlike progesterone, the lordosis-facilitating effect of clonidine was not accompanied by a subsequent refractory period. Clonidine had a weak lordosis facilitatory effect when administered during the decline in receptivity to estrogen plus progesterone-primed animals and failed to induce lordosis when administered during the refractory period.

AB - Lordosis behavior was induced in previously unreceptive, ovariectomized estrogen-primed female guinea pigs by administration of the noradrenergic agonist clonidine. Clonidine also enhanced lordosis responding in females that were weakly receptive after estrogen priming. Unlike progesterone, the lordosis-facilitating effect of clonidine was not accompanied by a subsequent refractory period. Clonidine had a weak lordosis facilitatory effect when administered during the decline in receptivity to estrogen plus progesterone-primed animals and failed to induce lordosis when administered during the refractory period.

KW - Clonidine

KW - Estrogen

KW - Lordosis

KW - Progesterone

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U2 - 10.1016/0091-3057(78)90339-8

DO - 10.1016/0091-3057(78)90339-8

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AN - SCOPUS:0017886691

SN - 0091-3057

VL - 8

SP - 207

EP - 209

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 2

ER -

Facilitation of lordosis behavior by clonidine in female guinea pigs

Abstract

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