Facilitation of lordosis behavior by clonidine in female guinea pigs

William R. Crowley, Bruce L. Nock, Harvey H. Feder

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Lordosis behavior was induced in previously unreceptive, ovariectomized estrogen-primed female guinea pigs by administration of the noradrenergic agonist clonidine. Clonidine also enhanced lordosis responding in females that were weakly receptive after estrogen priming. Unlike progesterone, the lordosis-facilitating effect of clonidine was not accompanied by a subsequent refractory period. Clonidine had a weak lordosis facilitatory effect when administered during the decline in receptivity to estrogen plus progesterone-primed animals and failed to induce lordosis when administered during the refractory period.

Original languageEnglish
Pages (from-to)207-209
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Issue number2
StatePublished - Feb 1978


  • Clonidine
  • Estrogen
  • Lordosis
  • Progesterone


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